普瑞巴林对肺楔形切除术后急性疼痛影响的回顾性队列研究  

Effect of Oral Pregabalin on Acute Pain after Pulmonary Wedge Resection:A Retrospective Cohort Study

作　　者：林秀钦[1] 杨爱琴 俞丽丽 LIN Xiu-qin;YANG Ai-qin;YU Li-li(Clinical pharmacy department,Fuqing city hospital,Fuqing 350300,Chian)

机构地区：[1]福清市医院临床药学室,福建福清350300

出　　处：《海峡药学》2024年第1期90-93,共4页Strait Pharmaceutical Journal

摘　　要：目的 探讨普瑞巴林对肺楔形切除术后急性疼痛的治疗作用。方法 收集2018年至2020年进行肺癌楔形切除手术的患者,采用回顾性队列研究,根据是否使用普瑞巴林分为两组,普瑞巴林组和非普瑞巴林组。采用倾向性评分1∶1匹配筛选合适病例后,对普瑞巴林的疗效以及两组术后阿片类药物、非甾体类药物使用量进行统计分析。结果 本研究最终共纳入186例患者,每组各93例,与非普瑞巴林组相比,普瑞巴林组手术后24 h、48 h的NRS评分降低,差异有统计学意义(P<0.05);两组阿片类药物使用量差异无统计学意义(P>0.05);两组术后阿片类药物和非甾体类抗炎药物的总DDDs差异无统计学意义(P>0.05)。结论 术后1日2次口服75 mg普瑞巴林可以缓解肺楔形切除术后疼痛。OBJECTIVE To investigate the therapeutic effect of pregabalin on acute pain after wedge-shaped resection of lung.METHODS The patients who underwent wedge-shaped resection of lung cancer from 2018 to 2020 were collected and divided into two groups,the pregabalin group and the non pregabalin group according to whether or not pregabalin was used.After selecting the appropriate cases with propensity score of 1∶1,the efficacy of pregabalin and the use of opioids and non steroids in the two groups were statistically analyzed.RESULTS A total of 186 patients were included in this study,93 cases in each group.Compared with the non pregabalin group,the NRS score of pregabalin group at 24 h and 48 h after operation decreased,and the difference was statistically significant(P<0.05);There was no significant difference in the use of opioids between the two groups(P>0.05);There was no significant difference in the total DDDs of opioids and NSAIDs between the two groups(P>0.05);There was no significant difference in the total hospitalization expenses between the two groups(P>0.05).CONCLUSION After operation,oral administration of 75 mg pregabalin twice a day can relieve the pain after pulmonary wedge resection.

关 键 词：肺楔形切除 普瑞巴林 急性疼痛 回顾性队列研究 

分 类 号：R969.4[医药卫生—药理学]