多黏菌素类药物神经毒性研究进展  

Research progress on neurotoxicity of polymyxins

作　　者：杨锐 向德标 袁芳 杨圆 王鹏凯 李昕 YANG Rui;XIANG Debiao;YUAN Fang;YANG Yuan;WANG Pengkai;LI Xin(Hunan University of Chinese Medicine,Changsha,Hunan,410208;the Third Hospital of Changsha City in Hunan Province,Changsha,Hunan,410015;Changsha Institute of Clinical Application of Antibiotics in Hunan Province,Changsha,Hunan,410015;Hunan Provincial Key Laboratory of Anti-Resistance Microbial Drugs,Changsha,Hunan,410015)

机构地区：[1]湖南中医药大学,湖南长沙410208 [2]湖南省长沙市第三医院,湖南长沙410015 [3]湖南省长沙市抗菌药物临床应用研究所,湖南长沙410015 [4]抗耐药微生物药物湖南省重点实验室,湖南长沙410015

出　　处：《实用临床医药杂志》2024年第2期135-141,共7页Journal of Clinical Medicine in Practice

基　　金：湖南省科学技术厅湖南省重点实验室项目(2023TP1013)。

摘　　要：多黏菌素类药物是抗多药耐药革兰氏阴性菌感染的最后保障,但是神经毒性限制了其临床应用。本文探讨多黏菌素类药物的分子结构及该类药物的神经毒性的临床表现、毒性机制、防治措施,指出已有研究对神经毒性报道的不足之处,以现有文献为基础,尝试将多黏菌素类药物的每日剂量和神经毒性表现进行联系,以期为临床上多黏菌素类药物的合理应用和神经毒性防治提供参考。Polymyxins are the last resort for the treatment of multidrug-resistant Gram-negative bacterial infections,but their neurotoxicity limits their clinical application.This paper discussed the molecular structure of polymyxins as well as the clinical manifestations,toxicity mechanisms,and prevention measures of their neurotoxicity,and it also pointed out the shortcomings of existing researches on neurotoxicity reports,and attempted to correlate the daily dose of polymyxins with neurotoxicity manifestations based on existing literatures,providing a reference for the rational use of polymyxins and the prevention of neurotoxicity in clinical practice.

关 键 词：黏菌素 多黏菌素B 分子结构 神经毒性 机制 保护剂 

分 类 号：R978.1[医药卫生—药品] R969.3[医药卫生—药学] R453.2