磁共振SWI序列联合血清Id1、IGFBP-3对脑胶质瘤术前分级的评估价值  

The Evaluation Value of Magnetic Resonance SWI Sequence Combined with Serum ld1 and IGFBP-3 in Preoperative Grading of Glioma

作　　者：刘梦雯 赵森[1] Liu Meng-wen;Zhao Sen(Medical Imaging Department of the First Affiliated Hospital of Henan University,Kaifeng 475002,Henan Province,China)

机构地区：[1]河南大学第一附属医院医学影像科,河南开封475002

出　　处：《中国CT和MRI杂志》2024年第2期5-7,共3页Chinese Journal of CT and MRI

基　　金：2022年度开封市科技发展计划项目(2207007)。

摘　　要：目的分析磁共振磁敏感加权成像(SWI)序列联合血清分化抑制因子1(Id1)、胰岛素样生长因子结合蛋白-3(IGFBP-3)对脑胶质瘤术前分级的评估价值。方法选取2019年12月至2022年6月我院收治的脑胶质瘤患者98例作为此次研究对象,根据恶化情况分为低级别组(世界卫生组织Ⅰ级和Ⅱ级)46例,高级别组(世界卫生组织Ⅲ级和Ⅳ级)52例;入选患者均进行磁共振SWI序列检查;采用酶联免疫吸附(ELISA)法检测血清Id1、IGFBP-3水平;采用Pearson法分析血清Id1、IGFBP-3水平的相关性;受试者工作特征(ROC)曲线分析Id1、IGFBP-3水平对脑胶质瘤术前分级的临界诊断点;采用四格表分析磁共振SWI序列联合血清Id1、IGFBP-3对脑胶质瘤术前高低级别的诊断价值。结果高级别组ITSS分级显著高于低级别组(P>0.05)。高级别组Id1、IGFBP-3水平均显著高于低级别组(P>0.05)。根据pearson相关性分析得知,脑胶质瘤患者血清Id1、IGFBP-3水平呈正相关(r=0.486,P<0.05)。根据ROC曲线得知,Id1、IGFBP-3诊断脑胶质瘤术前分级的曲线下面积(AUC)分别为0.837、0.861,二者联合诊断脑胶质瘤术前分级的AUC为0.908。磁共振SWI序列在脑胶质瘤术前分级诊断中准确度为83.67%,灵敏度为84.62%,特异度为82.61%;Id1在脑胶质瘤术前分级诊断中准确度为79.59%,灵敏度为80.77%,特异度为78.26%;IGFBP-3在脑胶质瘤术前分级诊断中准确度为81.63%,灵敏度为82.69%,特异度为80.43%;三者联合检测在脑胶质瘤术前分级诊断中准确度为91.84%,灵敏度为92.31%,特异度为91.30%。结论Id1、IGFBP-3在脑胶质瘤患者血清中显著升高,磁共振SWI序列联合血清Id1、IGFBP-3可以提高对脑胶质瘤术前分级的评估价值。Objective To analyze the evaluation value of magnetic resonance susceptibility weighting imaging(SWI)sequence combined with serum inhibitor of differentiation 1(Id1)and insulin-like growth factor-binding protein-3(IGFBP-3)in preoperative grading of glioma.Methods A total of 98 glioma patients admitted to our hospital from December 2019 to June 2022 were regarded as the study subjects,according to the worsening situation,they were divided into 46 cases in the low-level group(World Health Organization LevelⅠandⅡ)and 52 cases in the high-level group(World Health Organization LevelⅢandⅣ);all selected patients underwent magnetic resonance SWI sequence examination;enzyme linked immunosorbent assay(ELISA)was applied to detect serum levels of Id1 and IGFBP-3;Pearson method was applied to analyze the correlation between serum Id1 and IGFBP-3 levels;receiver operating characteristic(ROC)curve was applied to analyze the critical diagnostic points of Id1 and IGFBP-3 levels for preoperative grading of gliomas;four grid table was applied to analyze the diagnostic value of magnetic resonance SWI sequence combined with serum Id1 and IGFBP-3 for preoperative high and low levels of glioma.Results The ITSS grading of the high-level group was obviously higher than that of the low-level group(P>0.05).The levels of Id1 and IGFBP-3 in the high-level group were obviously higher than those in the low-level group(P>0.05).According to Pearson correlation analysis,there was a positive correlation between serum Id1 and IGFBP-3 levels in glioma patients(r=0.486,P<0.05).According to the ROC curve,the area under the curve(AUC)for Id1 and IGFBP-3 in diagnosing preoperative grading of glioma was 0.837 and 0.861,respectively,the AUC of the combination of the two in diagnosing preoperative grading of glioma was 0.908.The accuracy,sensitivity,and specificity of magnetic resonance SWI sequence in preoperative grading diagnosis of gliomas were 83.67%,84.62%,and 82.61%,respectively;the accuracy,sensitivity,and specificity of Id1 in preoperative

关 键 词：磁共振 磁敏感加权成像 分化抑制因子1 胰岛素样生长因子结合蛋白-3 脑胶质瘤 

分 类 号：R445.2[医药卫生—影像医学与核医学]