基于“胃不和则卧不安”理论探讨肠道菌群对失眠的作用机制  

flExploring the mechanism of intestinal flora on insomnia based on the theory of"stomach disorders leading to restless sleep"

作　　者：刘杨圣洁[1] 张红石[1] 矫俊东[2] 郑旭[1] 纪媛媛 郅晓宇 刘家邑 佟雪 刘鹏[1,3] LIU Yangshengjie;ZHANG Hongshi;JIAO Jundong;ZHENG Xu;JI Yuanyuan;ZHI Xiaoyu;LIU Jiayi;TONG Xue;LIU Peng(Changchun University of Chinese Medicine,Changchun 130117,China;Affiliated Hospital of Changchun University of Chinese Medicine,Changchun 130021,China;Shenzhen Hospital of Guangzhou University of Chinese Medicine,Shenzhen 510006,China)

机构地区：[1]长春中医药大学,长春130117 [2]长春中医药大学附属医院,长春130021 [3]广州中医药大学深圳医院<福田>,广东深圳510006

出　　处：《吉林中医药》2024年第2期134-139,共6页Jilin Journal of Chinese Medicine

基　　金：国家自然基金面上项目(82074569);吉林省自然科学基金项目(20210101211JC)。

摘　　要：《素问·逆调论》中记载“胃不和则卧不安”。然而由饮食不节引起的失眠,此病症的发病机制尚不清楚。现代研究发现,肠道菌群作为肠和脑的中间纽带,将胃肠道系统与中枢神经系统联系起来,这与中医论述的“胃不和则卧不安”的观点不谋而合。本文以肠道菌群为出发点,探讨胃肠不舒与失眠发生的内在联系,将现代发病机制与中医理论结合起来,以明确“胃不和则卧不安”的发病机制,为治疗失眠提供新思路。The Su Wen:Inverse Regulation Discourse has an account that"if the stomach is not harmonious,sleep is disturbed."However,the pathogenesis of insomnia caused by irregular diet is not yet clear.Modern research has found that gut microbiota serves as a bridge between the gastrointestinal system and the central nervous system and connects them,which aligns with the traditional Chinese medical viewpoint of"stomach disharmony leading to restless sleep".This article takes the intestinal flora as a starting point to explore the intrinsic connection between gastrointestinal discomfort and the onset of insomnia.By integrating the modern pathogenesis of insomnia with the traditional Chinese medicine theory,this study aims to clarify the pathogenesis of"stomach disorders leading to restless sleep",providing a new perspective for the treatment of insomnia.

关 键 词：胃不和 卧不安 失眠 肠道菌群 

分 类 号：R256.23[医药卫生—中医内科学]