基于皮肤屏障功能、氧化应激指标评估疏肝消斑汤联合YAG激光治疗黄褐斑的临床效果  

To evaluate the clinical effect of Shugan Xiaobang Decoction combined with YAG laser on melasma based on skin barrier function and oxidative stress index

作　　者：张作军 周树明[2] 高金丽 ZHANG Zuo-jun;ZHOU Shu-ming;GAO Jin-li(Department of Dermatology and Venereology,Affiliated Hospital of Xinyang Vocational and Technical College,Henan Province,464000,China;Department of Urology,The First Affiliated Hospital of Henan University of Chinese Medicine,Henan Province,450000,China;Plastic Surgery Department,Xinyang Central Hospital,Henan Province,464000,China)

机构地区：[1]信阳职业技术学院附属医院皮肤性病科,河南信阳464000 [2]河南中医药大学第一附属医院,泌尿外科,河南郑州450000 [3]信阳市中心医院,整形外科,河南信阳464000

出　　处：《中国医疗美容》2024年第1期47-50,共4页China Medical Cosmetology

摘　　要：目的分析基于皮肤屏障功能、氧化应激指标评估疏肝消斑汤联合YAG激光治疗黄褐斑的可行性。方法选取108例信阳职业技术学院附属医院收治的黄褐斑患者,选例时间:2021年8月至2023年3月,分为对照组(54例)和研究组(54例),分为对照组和研究组,对照组接受YAG激光治疗,研究组接受疏肝消斑汤联合YAG激光治疗,两组均连续治疗20周。比较两组治疗后临床疗效,治疗前后皮损情况及皮肤屏障功能、血清超氧化物歧化酶(SOD)、丙二醛(MDA)、脂质过氧化物(LPO)水平、皮肤病生存质量指数(DLQI)、抑郁自评量表(SDS)、焦虑自评量表(SAS)和肝郁气滞证评分情况。结果研究组临床总有效率较高(两组治疗后相比);两组皮损面积、皮损颜色积分、皮损区经表皮水分流失值、黑色素含量、DLQI、SDS、SAS、肝郁气滞证评分、血清MDA、LPO水平均降低(治疗后相较于治疗前),且研究组处于较低水平(组间进行对比);两组角质层含水量、血清SOD水平均升高(治疗后相较于治疗前),且研究组处于较高水平(组间进行对比),P<0.05。结论黄褐斑患者应用疏肝消斑汤联合YAG激光治疗,可有助于改善皮肤屏障功能、心理状态,缓解临床症状,抑制氧化应激反应,提升生活质量,且临床疗效显著。Objective To evaluate the feasibility of Shugan Xiaobang Decoction combined with YAG laser in the treatment of melasma based on skin barrier function and oxidative stress indexes.Methods 108 patients with melasma admitted to the Affiliated Hospital of Xinyang Vocational and Technical College were selected from August 2021 to March 2023 and divided into control group(54 cases)and research group(54 cases).The grouping method was random number table.The control group received YAG laser treatment,and the study group received Shugan Xiaoban decoction combined with YAG laser treatment.Both groups were treated for 20 weeks continuously.The clinical efficacy,skin lesions,skin barrier function,serum superoxide dismutase(SOD),malondialdehyde(MDA),lipid peroxides(LPO)levels,skin disease quality of life index(DLQI),self-rating Depression Scale(SDS),self-rating Anxiety Scale(SAS)and liver depression syndrome score before and after treatment were compared between the two groups.Results The total clinical effective rate of the study group was higher(compared with the two groups after treatment).Skin area,skin color score,transepidermal water loss value,melanin content,DLQI,SDS,SAS,liver stagnation syndrome score,serum MDA and LPO levels were all decreased in both groups(compared with before treatment),and the levels in the study group were lower(compared between groups).The water content of stratum corneum and the level of serum SOD in both groups were increased(after treatment compared with before treatment),and the level in the study group was higher(compared between groups),both P<0.05.Conclusion Shugan Xiaoban Decoction combined with YAG laser therapy can help improve skin barrier function,psychological state,relieve clinical symptoms,inhibit oxidative stress reaction and improve quality of life in patients with melasma,and the clinical effect is significant.

关 键 词：黄褐斑 疏肝消斑汤 激光 皮肤屏障功能 氧化应激 

分 类 号：R758.42[医药卫生—皮肤病学与性病学]