用于增强多金属氧酸盐抗肿瘤功效的靶向聚合物纳米颗粒  

Targeted polymeric nanoparticles for enhanced antitumor efficacy of polyoxometalates

作　　者：万冬[1] 张煜英 王欢[1] 姚田子 郭建辉[1] 刘钰君 张赛晖[1] 潘杰[1] WAN Dong;ZHANG Yuying;WANG Huan;YAO Tianzi;GUO Jianhui;LIU Yujun;ZHANG Saihui;PAN Jie(School of Chemistry and Chemical Engineering,Tiangong University,Tianjin 300387,China)

机构地区：[1]天津工业大学化学工程与技术学院,天津300387

出　　处：《化学工业与工程》2023年第5期144-150,共7页Chemical Industry and Engineering

基　　金：国家自然科学基金项目(22178270,22078246);天津市级大学生创新训练项目(202210058172)。

摘　　要：多金属氧酸盐(POMs)是一类很有前景的医药制剂,被用于抗癌、抗菌等方面。但其水溶性差,与正常细胞有非特异性的相互作用,导致了对肝脏和肾脏的毒副作用,这些都限制了它们在临床上的实际应用。用靶向分子修饰的聚合物纳米颗粒(Nanoparticles, NPs)可以解决POMs的这些问题。在此,设计了包裹POMs的新型聚合物NPs(PLA-mPEG_(1000)/TPGS_(3350)-Folate),用于将POMs靶向输送到肿瘤细胞。与没有靶向功能的NPs相比,这些用叶酸(FOL)修饰的NPs在体外对MCF-7黑色素癌细胞显示出很高的抗肿瘤活性,这可能是由于通过叶酸受体介导的内吞途径增强了细胞的吸收能力。设计的这些NPs在未来治疗癌症方面具有巨大的潜力。Polyoxometalates(POMs)works as a promising agent in medicine.They are exploited for an-ticancer,antibacterial,and so on.But they have poor water solubility and nonspecific interactions with normal cells,resulting in toxicity side effects on liver and kidney,all of which limit their practical appli-cation for antitumor in clinic.Polymeric nanoparticles(NPs)modified with targeting molecule can solve these problems of POMs.Herein,novel polymeric NPs(PLA-mPEG_(1000)/TPGS_(3350)-Folate)encapsulating POMs were developed for targeted delivery of POMs to tumor cells.In comparison with NPs without tar-geting function,these NPs decorated with folate(FOL)illustrated high antitumor activity to MCF-7 mel-anoma cells in vitro,which is perhaps due to enhanced cellular take through folate receptor-mediated en-docytosis pathway.As a result,it is supposed that these NPs designed in this work have enormous poten-tial for the treatment of cancer in the future.

关 键 词：金属 癌症 纳米颗粒 靶向 叶酸 

分 类 号：R944[医药卫生—药剂学]