染色体多态性对IVF/ICSI-ET妊娠结局的影响  

Effects of chromosomal polymorphisms on the outcome of IVF/ICSI-ET

作　　者：李华锋 顾玉婷 武传叶 LI Hua-feng;GU Yu-ting;WU Chuan-ye(Linyi Maternal&Child Health Hospital,Linyi 276000)

机构地区：[1]临沂市妇幼保健院,临沂276000

出　　处：《生殖医学杂志》2024年第2期174-179,共6页Journal of Reproductive Medicine

摘　　要：目的探讨在不孕不育夫妇中染色体多态性与体外受精/卵胞浆内单精子注射-胚胎移植(IVF/ICSI-ET)妊娠结局的关系。方法回顾性分析2020年1月至2022年1月于临沂市妇幼保健院生殖医学科因不孕症首次接受IVF/ICSI助孕治疗并进行新鲜胚胎移植的382例不孕不育夫妇的临床资料。按照染色体多态性结果分为女方多态性组(n=22)、男方多态性组(n=23)、正常组(n=337),比较3组患者的基础资料及其妊娠结局。结果382例不孕不育夫妇中检出染色体多态性患者45例,发生率为11.78%(45/382)。3组患者在女方年龄、男方年龄、体质量指数、不孕年限、抗苗勒管激素(AMH)水平、基础卵泡刺激素(FSH)水平、基础窦卵泡数以及受精方式、不育因素、不育类型等方面比较均无显著性差异(P>0.05)。3组患者间促排卵方案、促性腺激素总用量、HCG日子宫内膜厚度、获卵数、MⅡ卵数、受精卵数、2PN数、优胚数等方面差异无统计学意义(P>0.05)。3组患者新鲜胚胎移植周期的胚胎种植率、生化妊娠率、临床妊娠率、流产率、早产率、活产率比较均无显著差异(P>0.05)。结论染色体多态性对IVF/ICSI-ET助孕患者的妊娠结局无明显影响。Objective:To investigate the impacts of chromosomal polymorphisms on pregnancy outcomes in infertile couples who undergo fresh embryo transfer after in vitro fertilization or intracytoplasmic sperm injection-embryo transfer(IVF/ICSI-ET).Methods:Three hundred and eighty-two infertile couples who underwent the first IVF/ICSI-ET fertility treatment with fresh embryo transfer for infertility at the Department of Reproductive Medicine,Linyi Maternal&Child Health Hospital from January 2020 to January 2022 were retrospectively analyzed.The patients were divided into three groups:female polymorphism group(n=22),male polymorphism group(n=23),and the normal group(n=337).Results:Among 382 infertile couples,45 cases of chromosomal polymorphism were detected,with an incidence rate of 11.78%(45/382).There were no significant differences in terms of female age,male age,body mass index,infertility duration,concentrations of anti-Müllerian hormone(AMH),basal follicle-stimulating hormone level,the number of basal antral follicles,as well as the mode of fertilization,infertility factors,infertility type among the three groups(P>0.05).There were no significant differences in ovulation regimen,total dose of gonadotropin used,endometrial thickness on the day of human chorionic gonadotropin(HCG),the number of oocytes retrieved,the number of MⅡoocytes,the number of fertilized oocytes,the number of 2PN,and the number of top-quality embryos among the three groups(P>0.05).All three groups of patients had similar embryo implantation rate,biochemical pregnancy rate,clinical pregnancy rate,miscarriage rate,preterm birth rate,and live birth rate in fresh embryo transfer cycles(P>0.05).Conclusions:Chromosomal polymorphism has no significant impact on pregnancy outcomes in patients undergoing IVF/ICSI-ET.

关 键 词：染色体多态性 体外受精/卵胞浆内单精子注射-胚胎移植 妊娠结局 

分 类 号：R715.5[医药卫生—妇产科学] R711.6[医药卫生—临床医学]