卵母细胞及早期胚胎脂代谢的研究进展  

Advances in lipid metabolism of oocytes and early embryos

作　　者：贾洪燕 崔毓桂[1] JIA Hong-yan;CUI Yu-gui(Clinical Center of Reproductive Medicine,First Affiliated Hospital of Nanjing Medical University,Nanjing 210029;Lianyungang Maternity and Childcare Hospital,Kangda College of Nanjing Medical University,Lianyungang 222000)

机构地区：[1]南京医科大学第一附属医院生殖医学中心,南京210029 [2]南京医科大学康达学院附属连云港市妇幼保健院,连云港222000

出　　处：《生殖医学杂志》2024年第2期259-264,共6页Journal of Reproductive Medicine

基　　金：国家自然科学基金(81730041);国家重点研发项目(2017YFC1001602)。

摘　　要：脂代谢为卵母细胞发育成熟及早期胚胎发育过程提供能量,且代谢中间产物具有多种细胞生物学功能,包括生物膜构建、细胞信号传导、类固醇前体产生和代谢。卵母细胞还可以通过卵丘细胞从卵泡液获得脂质及其代谢物,尤其是胆固醇、高密度脂蛋白、甘油三酯、游离脂肪酸、载脂蛋白A1、肉碱。多囊卵巢综合征(PCOS)、肥胖、高龄、代谢紊乱、卵巢低反应(POR)等人群中卵母细胞脂代谢的异常与卵母细胞及其胚胎质量差密切相关。本文将综述卵母细胞减数分裂及早期胚胎发育过程中的脂代谢,为不孕症女性和高龄女性的个体化辅助生殖治疗提供理论支持,也有益于创新与改进未成熟卵母细胞体外培养液。Lipid metabolism provides energy for the development and maturation of oocyte,as well as the early embryonic development.Meanwhile,the intermediate products of lipid metabolism play multiple biological roles in oocyte,such as the construction of biological membrane,cell signaling,steroid precursors and metabolisms.Oocyte may also obtain lipids and metabolic products from the follicular fluid through cumulus cells,including especially cholesterol,high-density lipoprotein,triglycerides,free fatty acids,apolipoprotein A1 and carnitine.There are differences in the lipid metabolism and intermediate products among those people with polycystic ovary syndrome,obesity and metabolic disorders,advanced age and poor ovarian response,which is related to the poor quality of oocytes and embryos.This review discusses the lipid metabolism in oocyte meiosis and early embryonic development,so as to provide theoretical support for the individualized diagnosis and the treatment of infertile and ageing women,and also for innovating and improving in vitro culture medium.

关 键 词：卵母细胞 早期胚胎 脂代谢 卵泡液 高龄女性 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]