孕晚期妊娠期高血压患者血清串珠素、神经纤毛蛋白-1水平与病情、围生结局的关系  

Relationship between serum perlecan,neurociliin-1 levels and disease condition,perinatal outcome of gestational hypertension patients in late pregnancy

作　　者：张金玲[1] 郭利红[2] 王小洁 ZHANG Jinling;GUO Lihong;WANG Xiaojie(Second Department of Obstetrics and Gynecology,Handan Maternal and Child Health Hospital,Handan,Hebei 056002,China;First Department of Obstetrics and Gynecology,Handan Maternal and Child Health Hospital,Handan,Hebei 056002,China;Department of Gynecology of Traditional Chinese Medicine,Handan Maternal and Child Health Hospital,Handan,Hebei 056002,China)

机构地区：[1]邯郸市妇幼保健院产二科,河北邯郸056002 [2]邯郸市妇幼保健院产一科,河北邯郸056002 [3]邯郸市妇幼保健院中医妇科,河北邯郸056002

出　　处：《国际检验医学杂志》2024年第4期495-499,共5页International Journal of Laboratory Medicine

摘　　要：目的 探讨孕晚期妊娠期高血压患者血清串珠素(perlecan)、神经纤毛蛋白-1(NRP-1)水平与病情、围生结局的关系。方法 将2021年1月至2023年1月该院收治的103例孕晚期妊娠期高血压患者作为研究对象,根据病情严重程度将其分为单纯高血压组46例、轻度子痫组35例、重度子痫组22例。记录患者的围生结局情况,分为结局良好组72例和结局不良组31例。采用酶联免疫吸附试验法检测血清perlecan、NRP-1水平,采用受试者工作特性(ROC)曲线分析探讨血清perlecan、NRP-1对孕晚期妊娠期高血压患者围生结局的预测价值,采用多因素Logistic回归分析探讨孕晚期妊娠期高血压患者围生结局的影响因素。结果 轻度子痫组、重度子痫组血清perlecan、NRP-1水平低于单纯高血压组,差异有统计学意义(P<0.05);重度子痫组血清perlecan、NRP-1水平低于轻度子痫组,差异有统计学意义(P<0.05)。结局良好组血清perlecan、NRP-1水平高于结局不良组,差异有统计学意义(P<0.05)。血清perlecan、NRP-1两项指标联合预测孕晚期妊娠期高血压患者围生结局的临床效能优于单项指标预测。结局不良组年龄≥35岁占比、孕前体重指数(BMI)≥24 kg/m2占比、有流产史占比、收缩压、舒张压、24 h尿蛋白高于结局良好组,差异有统计学意义(P<0.05)。多因素Logistic回归分析结果显示,孕前BMI≥24 kg/m2、有流产史、收缩压高、perlecan≤8.63 nmol/L、NRP-1≤4.37 ng/mL是孕晚期妊娠期高血压患者不良围生结局的独立危险因素(P<0.05)。结论 血清perlecan、NRP-1水平降低与孕晚期妊娠期高血压患者的病情加重及不良围生结局有关,两项指标可作为预测患者围生结局的生物学标志物。Objective To explore the relationship between the levels of serum perlecan and neurociliin-1(NRP-1)and disease condition,perinatal outcome of gestational hypertension patients in late pregnancy.Methods A total of 103 gestational hypertension patients in late pregnancy admitted to the hospital from January 2021 to January 2023 were selected as the subjects of this study.According to the severity of the disease,they were divided into simple hypertension group(n=46),mild eclampsia group(n=35)and severe eclampsia group(n=22).The perinatal outcomes of the patients were recorded and divided into good outcome group(n=72)and poor outcome group(n=31).Serum perlecan and NRP-1 levels were detected by enzyme-related immunosorbent assay,and the predictive value of serum perlecan and NRP-1 on perinatal outcomes in gestational hypertension patients in late pregnancy was investigated by receiver operating characteristic(ROC)curve analysis.Multivariate Logistic regression analysis was used to investigate the influencing factors of perinatal outcomes in gestational hypertension patients in late pregnancy.Results The serum levels of perlecan and NRP-1 in mild eclampsia group and severe eclampsia group were lower than those in simple hypertension group,and the difference was statistically significant(P<0.05);Serum levels of perlecan and NRP-1 in severe eclampsia group were lower than those in mild eclampsia group,and the difference was statistically significant(P<0.05).The serum levels of perlecan and NRP-1 in the good outcome group were higher than those in the bad outcome group,and the difference was statistically significant(P<0.05).The clinical efficacy of serum perlecan and NRP-1 combined in predicting perinatal outcomes of gestational hypertension patients in late pregnancy was better than that of single index.The proportion of age≥35 years old,pre-pregnancy body mass index(BMI)≥24 kg/m 2,history of abortion,systolic blood pressure,diastolic blood pressure and 24 h urinary protein in the adverse outcome group were higher t

关 键 词：妊娠期高血压 孕晚期 串珠素 神经纤毛蛋白-1 围生结局 

分 类 号：R714.46[医药卫生—妇产科学]