在孤独中前行的卡里科--研制SARS-CoV-2 mRNA疫苗获得诺贝尔奖的生物化学家  

Walking in Solitude:Dr.Katalin Karik--Biochemist Who Wins Nobel Prize for Developing SARS-CoV-2 mRNA Vaccines

作　　者：于永利[1] YU Yong-Li(Department of Immunology,School of Basic Medical Sciences,Jilin University,Changchun 130021,Jilin Province,China)

机构地区：[1]吉林大学基础医学院免疫系,长春130021

出　　处：《中国生物化学与分子生物学报》2023年第12期1659-1663,共5页Chinese Journal of Biochemistry and Molecular Biology

摘　　要：2023年诺贝尔生理学/医学奖授予卡塔林·卡里科和德鲁·韦斯曼,表彰二者对研制严重急性呼吸系统综合征冠状病毒2的mRNA疫苗所做出的杰出贡献。本文回顾了生化学家卡里科在致力于mRNA成药研发中的艰辛历程,漫漫征途上不畏艰难的坚守和正确的选择是她成功的重要因素。mRNA修饰技术在未来会有更广泛的用途。The 2023 Nobel Prize in Physiology/Medicine has been awarded to Katalin Karik and Drew Weissman for their work on the development of mRNA vaccines against severe acute respiratory syndrome coronavirus 2.This article reviews the hard work of the biochemist Karik in the research and development of mRNA drugs.The persistence and the right choice on the long journey of scientific research are important factors for her success.We envision that the mRNA modification technique will be more widely used in the future.

关 键 词：mRNA疫苗 mRNA修饰 假尿嘧啶修饰 脂质纳米颗粒 

分 类 号：Q81[生物学—生物工程]