罗红霉素缓释片治疗急性咽炎扁桃体炎的疗效研究  

Effect of roxithromycin sustained-release tablets on acute pharyngitis tonsillitis

作　　者：张宗军 Zhang Zongjun(Binbei Street Community Health Service Center,Bincheng District,Binzhou City,Shandong Province,256600,China)

机构地区：[1]滨州市滨城区滨北街道社区卫生服务中心,山东滨州256600

出　　处：《中国医学文摘（耳鼻咽喉科学）》2024年第1期150-152,共3页Chinese Medical Digest(Otorhinolaryngology)

摘　　要：目的探究急性咽炎扁桃体炎用罗红霉素缓释片治疗的效果。方法2020年11月-2022年11月,从本院收治的急性咽炎扁桃体炎患者中选择72例,回顾病历资料,用随机分组依据将其分2组,各36例,对照组:常规药物治疗,试验组:联合罗红霉素缓释片治疗,比较临床症状缓解时间、血清炎性因子水平、治疗总有效率、不良反应发生率。结果咽痛、发热、扁桃体肿大、颌下淋巴结肿大、脓性分泌物等症状缓解时间相比,试验组短于对照组,P<0.05;治疗前对比两组炎性因子水平,即TNF-α、IL-1、IL-6水平,无差异,P>0.05,治疗后,炎性因子水平较治疗前下降,而且试验组TNF-α、IL-1、IL-6低于对照组,P<0.05;对比两组治疗总有效率,试验组为94.4%,对照组为75.0%,两组相比,试验组高于对照组,P<0.05;统计两组不良反应发生率,无差异,P>0.05。结论在急性咽炎扁桃体炎治疗中,采用罗红霉素缓释片治疗,可以在改善临床症状的同时降低机体炎性因子水平,对提升治疗效果有积极作用,值得推荐。Objective To explore the effect of roxithromycin sustained release tablets in the treatment of acute pharyngitis and tonsillitis.Methods From November 2020 to November 2022,72 patients with acute pharyngitis and tonsillitis admitted to our hospital were selected,medical records were reviewed,and they were randomly divided into 2 groups,36 cases each,control group:conventional drug treatment,experimental group:Combined with roxithromycin sustained-release tablets,clinical symptom remission time,serum inflammatory factor level,total effective rate,incidence of adverse reactions,quality of life were compared.Results Compared with the control group,the remission time of symptoms such as pharyngeal pain,fever,tonsil enlargement,submaxillary lymph node enlargement and purulent secretion was shorter in experimental group than in control group,P<0.05.Before treatment,there was no difference in the levels of inflammatory factors between the two groups,namely TNF-,IL-1 and IL-6,P>0.05.After treatment,the levels of inflammatory factors decreased compared with before treatment,and TNF-,IL-1 and IL-6 in the experimental group were lower than those in the control group,P<0.05.The total effective rate of the experimental group was 94.4%,and that of the control group was 75.0%.Compared with the two groups,the experimental group was higher than the control group,P<0.05.There was no difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion In the treatment of acute pharyngitis tonsillitis,the use of roxithromycin sustained-release tablets can improve clinical symptoms and reduce the level of inflammatory factors in the body,which has a positive effect on improving the therapeutic effect,and is worthy of recommendation.

关 键 词：急性咽炎扁桃体炎 罗红霉素缓释片 临床症状缓解时间 血清炎性因子水平 治疗总有效率 不良反应发生率 

分 类 号：R76[医药卫生—耳鼻咽喉科]