基于数据挖掘探讨中医药治疗血栓性浅静脉炎用药规律  

Discussion on medication law of TCM in treating superficial vein thrombosis based on data mining

作　　者：王唱 曹建春[2] 常金霞 Wang Chang;Cao Jianchun;Chang Jinxia(The Second Clinical Medical College of Beijing University of Chinese Medicine,Beijing 100029,China;Peripheral Vascular Department of Dongfang Hospital,Beijing University of Chinese Medicine,Beijing 100078,China)

机构地区：[1]北京中医药大学第二临床医学院,北京100029 [2]北京中医药大学东方医院周围血管科,北京100078

出　　处：《国际中医中药杂志》2024年第2期237-242,共6页International Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金(81874473)。

摘　　要：目的通过数据挖掘方法探讨中药治疗血栓性浅静脉炎(SVT)的用药规律。方法检索中国知识资源总库(CNKI)、中国学术期刊数据库(万方数据)、中文科技期刊数据库(重庆维普)建库至2022年11月27日有关中医药治疗SVT的文献, 采用WPS表格 12.1.0.15990对中药频次及其性味归经分布进行统计分析, 分别采用SPSS Modeler 18.0、SPSS Statistics 25.0软件, 对高频用药进行关联规则分析及聚类分析, 总结中医药治疗SVT的用药规律。结果纳入文献281篇, 包括内服方245首, 涉及中药182味;外用方123首, 涉及中药188味。其中, 内服中药的高频用药有当归、赤芍、牛膝等, 外用中药的高频用药有大黄、黄柏、红花等, 均以清热药和活血化瘀药为主。高频内服中药药性多为微寒、平、寒性, 药味以苦、甘味居多, 归经以肝、心、脾、肺经为主;高频外用中药药性多为寒、温性, 药味以苦、辛味为主, 归经以肝、心、脾、胃经为主。内服中药关联规则有22条, 外用中药关联规则有7条。聚类分析中, 内服中药可分为5类, 外用药可分为4类。结论中医药治疗SVT以清热、活血化瘀为基本治法, 随证搭配, 体现了中医的整体观念和辨证论治。Objective To explore the medication law of TCM in the treatment of superficial vein thrombosis(SVT)using data mining.Methods Literature about TCM in the treatment of SVT was retrieved from CNKI,Wanfang Data,and VIP from the establishment of the databases to November 27th,2022.WPS 12.1.0.15990 was used to conduct statistical analysis on drug frequency,property and taste and meridian.The association rules and systematic clustering were carried out by SPSS Modeler 18.0 and SPSS Statistics 25.0.Finally the medication law of TCM in the treatment of SVT was summarized and refined.Results A total of 281 articles were included,including 245 internal prescriptions with 182 kinds of Chinese materia medica,and 123 external prescriptions with 188 kinds of Chinese materia medica.The high frequency used oral Chinese materia medica were mainly Angelicae Sinensis Radix,Paeoniae Radix Rubra,Cyathulae Radix,while the high frequency drugs used externally mainly included Rhei Radix et Rhizoma,Phellodendri Chinensis Cortex,Carthami Flos.These Chinese materia medica were mainly heat-clearing and blood-stasis activators drugs.The medicinal properties of high frequency oral Chinese materia medica were mainly slightly cold,flat and cold,and the tastes were mainly bitter and sweet,and the meridian were mainly liver,heart,spleen and lung.The medicinal properties of high-frequency external Chinese materia medica were mainly cold and warm,and the tastes were mainly bitter and pungent,and the meridian were mainly liver,heart,spleen and stomach.There were 22 rules of association for internal TCM and 7 for external use.The clustering analysis divided oral drugs into 5 categories and topical drugs into 4 categories.Conclusion TCM treatment of SVT is based on clearing heat,activating blood circulation and resolving blood stasis,and matching with the syndromes,which reflects the holistic concept of TCM and the perspective of syndrome differentiation and treatment.

关 键 词：血栓性静脉炎 青蛇毒 中医药 数据挖掘 用药规律 

分 类 号：R259[医药卫生—中西医结合]