肾溶质清除率增加高发疾病动物模型建立研究  

Establishment of animal model of increased renal solute clearance

作　　者：杨舒 罗轶凡[1,2] 初阳[1] YANG Shu;LUO Yi-fan;CHU Yang(The First Clinical College of China Medical University,Shenyang 110001,Liaoning Province,China;Department of Pharmacy,The First Affiliated Hospital of China Medical University,Shenyang 110001,Liaoning Province,China)

机构地区：[1]中国医科大学第一临床学院,辽宁沈阳110001 [2]中国医科大学附属第一医院药学部,辽宁沈阳110001

出　　处：《中国临床药理学杂志》2024年第1期135-138,共4页The Chinese Journal of Clinical Pharmacology

摘　　要：临床常见脓毒症、烧伤、蛛网膜下腔出血、创伤性脑损伤等重症患者出现的肾溶质清除率增加,称为肾功能亢进(ARC)。当该类患者应用主要经肾排泄的药物后,药物无法达到有效的治疗浓度水平,从而增加治疗失败的风险。近些年这一现象越来越引起人们的关注,但因其发生机制尚不明确,也在一定程度上限制了用于ARC研究的动物模型的开发。因此基于ARC相关危险因素建立相应的动物模型对于深入研究ARC发生的机制具有重要意义。本文从临床ARC高发的疾病入手,对其相关的动物模型进行综述,旨在为ARC动物模型的开发提供参考。Clinically common patients with severe diseases such as sepsis,burns,subarachnoid hemorrhage,and traumatic brain injury have increased renal solute clearance,it’s called augmented renal clearance(ARC).When such patients are given drugs that are excreted mainly by the kidneys,the drug does not reach effective therapeutic concentration levels,thereby increasing the risk of treatment failure.In recent years,this phenomenon has attracted more and more attention,but because its mechanism is not clear,it also limits the development of animal models for ARC research to a certain extent.Therefore,it is of great significance to establish corresponding animal models based on ARC-related risk factors for in-depth study of the mechanism of ARC occurrence.This article reviews the related animal models from the diseases with high incidence of clinical ARC,aiming to provide reference for the development of ARC animal models.

关 键 词：肾溶质清除率增加 动物模型 脓毒症 烧伤 蛛网膜下腔出血 创伤性脑损伤 

分 类 号：R97[医药卫生—药品]