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作 者:李昱萱 张润琛 程爱新 马庆韬 付天聪 王冠然 徐枝芳 郭扬 LI Yu-xuan;ZHANG Run-chen;CHENG Ai-xin;MA Qing-tao;FU Tian-cong;WANG Guan-ran;XU Zhifang;GUO Yang(First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China;National Clinical Research Center for Chinese Acupuncture and Moxibustion,Tianjin 300193;Research Center of Experimental Acupuncture and Moxibustion Science,Tianjin University of Traditional Chinese Medicine,Tianjin 301617;Tianjin Key Laboratory of Acupuncture and Moxibustion,Tianjin 300193;Key Laboratory of Acupuncture Therapy for Cerebropathy of State Administration of Traditional Chinese Medicine,Tianjin 300000)
机构地区:[1]天津中医药大学第一附属医院,天津300193 [2]国家中医针灸临床医学研究中心,天津300193 [3]天津中医药大学实验针灸研究中心,天津301617 [4]天津市针灸学重点实验室,天津300193 [5]国家中医药管理局脑病针刺疗法重点研究室,天津300000
出 处:《针刺研究》2024年第1期71-78,共8页Acupuncture Research
基 金:国家自然科学基金青年基金项目(No.82004464);天津市自然科学基金青年基金项目(No.20JCQNJC00920);中华中医药学会青年人才托举工程项目[No.CACM-(2022-QNRC2-A09)]。
摘 要:针刺治疗缺血性卒中(IS)具有显著疗效。针刺治疗IS的作用与调控线粒体功能具有密切的联系。本文从线粒体结构、线粒体功能、线粒体质量控制、线粒体相关的细胞凋亡通路4个方面对线粒体在针刺治疗IS中的作用与相关机制进行综述,为针刺通过调控神经元线粒体治疗IS提供理论依据,为今后深入开展相关研究提供参考。Acupuncture has a positive effect in the treatment of ischemic stroke(IS). A number of studies have confirmed that the role of acupuncture in the treatment of IS, which is closely related to its functions of regulating mitochondrial functions. In the present article, we review the mechanisms of acupuncture underlying improvement of mitochondria in the treatment of IS from 4 aspects: 1) protecting mitochondrial structure integrity, 2) regulative effect on mitochondrial functional activities, including regulating energy metabolism, reducing oxidative stress, suppressing calcium overload, and regulating mitochondrial membrane potential changes, 3) regulating mitochondrial quality control system, including promoting mitochondrial biosynthesis, regulating mitochondrial dynamics and apoptosis, and 4) regulating mitochondria-related apoptosis pathways. All of these may provide a theoretical basis for acupuncture in the treatment of IS and a reference for further research.
分 类 号:R246.6[医药卫生—针灸推拿学]
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