高分子囊泡领域面临的挑战和未来研究方向  

Challenges and future directions for next-generation biomedical polymersomes

作　　者：石隽秋 孙青梅 王文立 李畅 尹海洋 李浩澜 滕润鑫 范震 朱云卿 杜建忠 Junqiu Shi;Qingmei Sun;Wenli Wang;Chang Li;Haiyang Yin;Haolan Li;Runxin Teng;Zhen Fan;Yunqing Zhu;Jianzhong Du(Department of Gynaecology and Obstetrics,Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation,Clinical Research Center for Anesthesiology and Perioperative Medicine,Translational Research Institute of Brain and Brain-Like Intelligence,Shanghai Fourth People’s Hospital,School of Medicine,Tongji University,Shanghai 200434,China;Department of Polymeric Materials,School of Materials Science and Engineering,Tongji University,Shanghai 201804,China)

机构地区：[1]Department of Gynaecology and Obstetrics,Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation,Clinical Research Center for Anesthesiology and Perioperative Medicine,Translational Research Institute of Brain and Brain-Like Intelligence,Shanghai Fourth People’s Hospital,School of Medicine,Tongji University,Shanghai 200434,China [2]Department of Polymeric Materials,School of Materials Science and Engineering,Tongji University,Shanghai 201804,China

出　　处：《Science China Materials》2024年第1期18-30,共13页中国科学（材料科学）（英文版）

基　　金：supported by the National Key R&D Program of China (2022YFC2402900);the National Natural Science Foundation of China (21925505,22335005,52003195,52222306,22075212,and 22175131);the Innovation Program of Shanghai Municipal Education Commission (2023ZKZD28);Shanghai International Scientific Collaboration Fund (21520710100)。

摘　　要：作为细胞中的主要运输系统,天然囊泡在物质的定点输运过程中具有至关重要的作用.高分子囊泡是与之结构相似的一种人工囊泡,具有优异的膜稳定性和胶体稳定性、高药物负载率、低膜穿透性、优异的可修饰性和长循环时间等优势,在生物医用领域具有广泛的应用前景.然而,目前该领域尚面临一系列重要挑战,如合成和制备方法较为复杂、生物相容性较难预测、功能和递送途径有限等,限制了其临床转化之路.本文从囊泡的构建模块合成、自组装技术和潜在的生物医学应用等角度,提出了设计和制备下一代高分子囊泡需要解决的五个关键科学问题,指出了未来面临的重要挑战和发展方向,例如简化设计和合成过程,优化和规范自组装过程,拓展潜在的应用前景.As a major transport system in cells,naturally occurring vesicles play an important role to ensure that the right cargo is shipped to the right destination at the right time.Similarly,artificial vesicles,such as polymersomes with simi-lar structures and functions,have been developed for various biological applications due to the advantages of polymersomes such as excellent membrane and colloidal stability,high loading efficiency of hydrophobic drugs,low membrane per-meability,high functional modifiability,and long circulation time.However,relatively complicated synthesis and prepara-tion methods,unpredictable biocompatibility and limited functions and delivery routes,have largely hindered the clinic translation of polymersomes.In this review,we propose five key scientific questions for next-generation polymersomes,in the aspects of synthesis of building blocks,self-assembly techniques,and potential biomedical applications,to empha-size on the future challenges and directions,such as simpli-fying the design and synthetic process,streamlining and standardizing the self-assembly procedure,and broadening the horizon of potential applications.

关 键 词：生物医学应用 胶体稳定性 自组装技术 运输系统 膜稳定性 输运过程 穿透性 高分子 

分 类 号：R318[医药卫生—生物医学工程] O631[医药卫生—基础医学]