功能磁共振研究元分析方法介绍及其在针刺领域的应用探析  

Introduction to the Meta-analysis method of functional magnetic resonance imaging research and the exploration of its application in the field of acupuncture

作　　者：葛文逸 刘巍 樊小农[1,2,3,4,5] 李仪丙 贾鸿博 雷康辰 李宋姣 常颖慧 GE Wenyi;LIU Wei;FAN Xiaonong;LI Yibing;JIA Hongbo;LEI Kangchen;LI Songjiao;CHANG Yinghui(First Teaching Hospital of Tianjin University of TCM,Tianjin 300193,China;National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion,Tianjin 300193;Tianjin Institute of Acupuncture and Moxibustion,Tianjin 300193;Tianjin Key Laboratory of Acupuncture and Moxibustion,Tianjin 300193;Laboratory of Dose-Effect Relationship,National Administration of TCM(Level 3),Tianjin 300193)

机构地区：[1]天津中医药大学第一附属医院,天津300193 [2]国家中医针灸临床医学研究中心,天津300193 [3]天津市针灸研究所,天津300193 [4]天津市针灸学重点实验室,天津300193 [5]国家中医药管理局针刺量效关系实验室(三级),天津300193

出　　处：《中国针灸》2024年第1期25-33,共9页Chinese Acupuncture & Moxibustion

基　　金：国家自然科学基金资助项目:82374578;国家重点研发计划项目:2018YFC1705004;天津市科技计划项目:21JCZDJC00890;天津市教委科研计划项目:2021ZD011。

摘　　要：近年来针刺领域功能磁共振成像(fMRI)研究数量不断增加,但由于腧穴选择、针刺手法以及样本量等差异,致使研究间结果分散、针刺共性规律不明的问题越发凸显。笔者以针刺治疗中风后运动障碍(PSMD)相关f MRI研究为例,引出并介绍了整合相关研究结果、提取共性规律的fMRI元分析技术:基于图像的元分析(IBMA)和基于坐标的元分析(CBMA)。鉴于CBMA的可实施性更高,故重点说明了3种可用的CBMA方法,即激活似然估计(ALE)、核密度分析(KDA)和基于种子的d映射(SDM);并以开展CBMA的注意事项、操作流程为切入点,对研究的fMRI类型、任务设计、分析方法以及开展fMRI元分析的整体思维考量过程进行了系统梳理,整理成图表,旨在帮助读者能够快速、方便、相对系统地对其中抽象复杂的理论和实战信息进行了解和理解,为其今后更深入地学习和应用起到抛砖引玉的作用。In recent years,the number of functional magnetic resonance imaging(fMRI)research in acupuncture grows increasingly.However,due to the differences in acupoint selection,acupuncture technique and sample size,the problems get more prominent in terms of the diverse results and the lack of common rules of acupuncture among researches.By taking the fMRI research for post-stroke motor dysfunction(PSMD)treated with acupuncture as the example,this paper introduces the fMRI Meta-analysis technology for integrating the relevant research results and extracting the common rules,namely imagebased Meta-analysis(IBMA)and coordinate-based Meta-analysis(CBMA).Considering the higher feasibility of CBMA,three available CBMA methods are explained specially,including activation likelihood estimation(ALE),kernel density analysis(KDA),and seed-based d mapping(SDM).Focusing on the precautions and operation procedure of CBMA,the review is conducted systematically on the type of fMRI research,task design,analytical method,and the thinking integrity of fMRI Meta-analysis,and the review findings are collated in charts.It aims to assist readers to understand the abstract and complex theories and practical information of this technology efficiently,conveniently and systematically,and hopes to provide the references for the future learning and the application.

关 键 词：针刺 功能磁共振成像 基于坐标的元分析 

分 类 号：R445.2[医药卫生—影像医学与核医学] R245[医药卫生—诊断学]