A review of structural modification and biological activities of oleanolic acid  

作　　者：YANG Huali DENG Minghui JIA Hongwei ZHANG Kaicheng LIU Yang CHENG Maosheng XIAO Wei 

机构地区：[1]State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process,Jiangsu Kanion Pharmaceutical Co.,Ltd.,Lianyungang 222001,China [2]Key Laboratory of Structure-Based Drug Design&Discovery of Ministry of Education,School of Pharmaceutical Engineering,Shenyang Pharmaceutical University,Shenyang 110016,China

出　　处：《Chinese Journal of Natural Medicines》2024年第1期15-30,共16页中国天然药物（英文版）

基　　金：supported by the Lianyungang Postdoctoral Research Funding Program(No.LYG20210018).

摘　　要：Oleanolic acid(OA),a pentacyclic triterpenoid,exhibits a broad spectrum of biological activities,including antitumor,antiviral,antibacterial,anti-inflammatory,hepatoprotective,hypoglycemic,and hypolipidemic effects.Since its initial isolation and identification,numerous studies have reported on the structural modifications and pharmacological activities of OA and its derivatives.Despite this,there has been a dearth of comprehensive reviews in the past two decades,leading to challenges in subsequent research on OA.Based on the main biological activities of OA,this paper comprehensively summarized the modification strategies and structureactivity relationships(SARs)of OA and its derivatives to provide valuable reference for future investigations into OA.

关 键 词：Oleanolic acid DERIVATIVES Pentacyclic triterpenoid Structural modification Biological activities 

分 类 号：R284[医药卫生—中药学] R965[医药卫生—中医学]