低氧诱导因子-1在低氧性肺动脉高压中的研究进展  

Hypoxia Inducible Factor-1 in Hypoxic Pulmonary Hypertension

作　　者：金鸿锦 卢义[1] 丁彦春[1] JIN Hongjin;LU Yi;DING Yanchun(The Second Hospital of Dalian Medical University,Dalian 116021,Liaoning,China)

机构地区：[1]大连医科大学附属第二医院,辽宁大连116021

出　　处：《心血管病学进展》2024年第1期35-39,共5页Advances in Cardiovascular Diseases

基　　金：辽宁省自然科学基金(2022-MS-325)。

摘　　要：低氧性肺动脉高压(HPH)是由缺氧引起的肺动脉压力进行性升高的肺血管疾病。低氧诱导因子-1(HIF-1)是维持细胞氧稳态的核心转录因子,可促进细胞糖代谢模式的转变、调节细胞膜表面离子通道活性、调节肺血管收缩及舒张因子活性等,在HPH的发生和发展中具有重要作用。现对HIF-1及其下游信号分子在HPH发生和发展中的作用机制进行综述,有助于为HPH的治疗提供新的理论依据和治疗靶点。Hypoxic pulmonary hypertension(HPH)is a pulmonary vascular disease resulted from progressive increase in pulmonary arterial pressure caused by hypoxia.Hypoxia inducible factor-1(HIF-1)is a core transcription factor which maintains cell oxygen homeostasis,promotes the transformation of glucose metabolism patterns,regulates the activity of the ion channel on the membrane surface and the pulmonary vasoconstriction and relaxation factors,which plays an important role in the occurrence and development of HPH.This review aims to investigate the mechanism of HIF-1 and its downstream signaling molecules in the occurrence and development of HPH,which will provide new theoretical basis and therapeutic target for the treatment of HPH.

关 键 词：低氧性肺动脉高压 低氧诱导因子-1 低氧性肺血管重塑 

分 类 号：R544.1[医药卫生—心血管疾病]