隔蒜灸联合2HRZE/4HR方案对气阴两虚型肺结核患者中医症候及痰菌阴转率的影响  

Impacts of Garlic Separated Moxibustion Combined with 2HRZE/4HR Regimen on TCM Symptom Score and Sputum Negative Conversion Rate in Patients with Pulmonary Tuberculosis of Deficiency of Both Qi and Yin

作　　者：倪磊磊 国美峰 李继翰 NI Leilei;GUO Meifeng;LI Jihan(Cangzhou Third Hospital,Cangzhou 061000,China)

机构地区：[1]沧州市第三医院,河北沧州061000

出　　处：《针灸临床杂志》2024年第2期16-20,共5页Journal of Clinical Acupuncture and Moxibustion

基　　金：河北省中医药管理局中医药类科学研究课题计划,编号:2023272。

摘　　要：目的:探究隔蒜灸联合2HRZE/4HR方案对气阴两虚型肺结核患者中医症候及痰菌阴转率的影响。方法:选择2019年1月—2022年1月本院收治的130例气阴两虚型肺结核患者,利用随机数字表法分为对照组(65例,采用2HRZE/4HR方案治疗)与研究组(65例,采用隔蒜灸联合2HRZE/4HR方案进行治疗),收集患者的临床资料并比较两组患者的临床疗效、中医症候积分、痰菌阴转率、炎症指标、免疫功能的变化情况及不良反应的发生率。结果:与对照组比较,研究组的总有效率显著增加(P<0.05)。治疗前,两组肺结核患者的痰菌阴转率、血清基质金属蛋白酶抑制剂-1(TIMP-1)、C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、CD4^(+)、CD8^(+)及CD4^(+)/CD8^(+)比较差异无统计学意义(P>0.05);治疗后,两组肺结核患者的TIMP-1、CRP、TNF-α及CD8^(+)降低(P<0.05),痰菌阴转率、CD4^(+)及CD4^(+)/CD8^(+)升高(P<0.05),且上述指标研究组改善的更为明显(P<0.05)。与对照组比较,研究组不良反应的总发生率显著降低(P<0.05)。结论:隔蒜灸联合2HRZE/4HR方案治疗气阴两虚型肺结核患者的效果确切,可降低患者中医症候积分及炎症因子水平,提高患者的痰菌阴转率及免疫功能,安全性高。Objective:To explore the impacts of garlic separated moxibustion combined with 2HRZE/4HR regimen on TCM symptom score and sputum negative conversion rate in patients with pulmonary tuberculosis of deficiency of both Qi and Yin.Methods:A total of 130 cases of patients with pulmonary tuberculosis of deficiency of both Qi and Yin were randomly divided into the control group(n=65)and the study group(n=65).The control group was treated with 2HRZE/4HR regimen;on which basis,the study group was also treated with garlic separated moxibustion.Clinical efficacy,TCM symptom score,sputum negative conversion rate,inflammatory indicators,changes in immune function,and incidence of adverse reactions were compared between the two groups.Results:Compared with those in the control group,the total effective rate of the study group obviously increased(P<0.05).There were no obvious difference in sputum negative conversion rate,serum matrix metalloproteinase-1(TIMP-1),C-reactive protein(CRP),tumor necrosis factor-α(TNF-α),CD4^(+),CD8^(+)and CD4^(+)/CD8^(+)between the two groups before the treatment(P>0.05);after the treatment,the levels of TIMP-1,CRP,TNF-αand CD8^(+)decreased(P<0.05),the sputum negative conversion rate,CD4^(+)and CD4^(+)/CD8^(+)increased in both groups(P<0.05);of which the improvements in the study group were more significant than those in the control group(P<0.05).The total incidence of adverse reactions was obviously lower in the study group than that in the control group(P<0.05).Conclusion:The combination of garlic separated moxibustion and 2HRZE/4HR regimen has a definite effect on patients with pulmonary tuberculosis of deficiency of both Qi and Yin.It can reduce TCM symptom score and inflammatory factor levels,and improve sputum negative conversion rate and immune function,with a high safety.

关 键 词：隔蒜灸 2HRZE/4HR方案 肺结核 中医症候 痰菌阴转率 

分 类 号：R246.1[医药卫生—针灸推拿学]