脂质体的制备方法及应用的研究进展  

Research progress in preparation methods and applications of liposomes

作　　者：王兴芝 代英辉[1] 王东凯[2] WANG Xingzhi;DAI Yinghui;WANG Dongkai(School of Traditional Chinese Medicine,Shenyang Pharmaceutical University,Shenyang 110016,China;School of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110016,China)

机构地区：[1]沈阳药科大学中药学院,辽宁沈阳110016 [2]沈阳药科大学药学院,辽宁沈阳110016

出　　处：《中国药剂学杂志（网络版）》2024年第1期14-24,共11页Chinese Journal of Pharmaceutics：Online Edition

摘　　要：目的综述脂质体的制备方法及应用的研究进展,旨在为脂质体的进一步研究与开发新功能提供思路。方法查阅近年来国内外关于脂质体研究的相关文献,并对其进行整理、归纳与总结。结果脂质体作为近几十年发现的一种高效载体,可由人工合成的磷脂化合物来制备,且制备方法日益完善,可根据药物的不同特性对脂质体进行结构修饰,在医药、基因工程、食品、化妆品等领域起着越来越重要的作用。结论脂质体在药物治疗及生活中有着重要的研究意义与应用前景。Objective To review the research progress of preparation methods and applications of liposomes in order to provide ideas for further research and development of new functions of liposomes.Methods The related literatures on liposomes at home and abroad in recent years were reviewed and summarized.Results Liposomes,as a highly efficient carrier discovered in recent decades,can be prepared from synthetic phospholipid compounds,and the preparation methods are becoming more and more perfect.Liposomes can be structurally modified according to the different characteristics of drugs,playing an increasingly important role in the fields of medicine,genetic engineering,food,cosmetics and so on.Conclusion Liposomes have important research significance and application prospect in drug therapy and life.

关 键 词：脂质体 主动载药 被动载药 研究进展 理化性质 

分 类 号：R94[医药卫生—药剂学]