抑郁症患者自杀观念与血清炎症因子和代谢指标的相关性  

Correlation between suicidal ideation of depression patients and serum inflammatory factors,metabolic index

作　　者：贾敏[1] 张欢 马亚伟 马青艳[1] 范雅娟 王崴[1] 马现仓[1] 高成阁[1] JIA Min;ZHANG Huan;MA Ya-wei;MA Qing-yan;FAN Ya-juan;WANG Wei;MA Xian-cang;GAO Cheng-ge(Department of psychiatry,The First Affiliated of Xi’an Jiaotong University,Xi’an 710061,China)

机构地区：[1]西安交通大学第一附属医院精神科,710061 [2]榆林市第五医院

出　　处：《临床精神医学杂志》2024年第1期13-16,共4页Journal of Clinical Psychiatry

基　　金：陕西省重点研发计划一般项目:社会发展领域(2022SF-417)。

摘　　要：目的:探索抑郁症患者自杀观念与血清代谢指标及炎症因子的相关性。方法:纳入2020年5月至2022年8月在我院精神心理科住院的首发抑郁症患者119例,根据汉密尔顿抑郁量表(Hamil-ton depression scale,HAMD)条目3“自杀”(H3)的评分进行分组,H3≥1分为有自杀观念组(74例),H3<1分为无自杀观念组(45例)。比较两组血清中代谢指标和炎症因子差异。采用相关性分析的方法分析抑郁症患者自杀观念与血清中代谢指标和炎症因子的相关性。结果:两组的炎症因子和代谢指标差异均有统计学意义,伴有自杀观念组患者血清中白细胞介素-2(IL-2)、白细胞介素-4(IL-4)、白细胞介素-10(IL-10)、白细胞介素-17(IL-17)水平均较无自杀观念组高(P均<0.05),代谢指标的比较发现有自杀观念组的肌酐水平低于无自杀观念组(P<0.05);相关分析发现IL-2(r=0.29,P<0.01)、IL-4(r=0.20,P=0.03)和IL-17(r=0.21,P=0.02)水平与H3的评分呈正相关,肌酐水平与H3的评分呈负相关(r=-0.22,P=0.02)。结论:伴有自杀观念的抑郁症患者肌酐代谢和血清炎症因子与无自杀观念者存在差异,且与自杀风险存在一定关联。Objective:To study the correlation between suicidal ideation of depression patients and meta-bolic index,serum inflammatory factors.Method:Total 119 patients who were hospitalized in the department of psychiatry of our hospital from May 2020 to August 2022 with first-episode depression were collected,we di-vided them into two groups according to the scores of Hamilton depression scale(HAMD)item 3“suicide”(H3).74 patients with H3≥1 was the group with suicidal ideation,and 45 patients with H3<1 was the group without suicidal ideation.Results:The levels of serum inflammatory factors and metabolic index were different between the two groups.The levels of interleukin-2(IL-2),interleukin-4(IL-4),interleukin-10(IL-10)and in-terleukin-17(IL-17)in the group with suicidal ideation were higher than those in the group without suicidal ide-ation(all P<0.05),while the creatinine level was lower(P<0.05),the difference was statistically signifi-cant.Correlation analysis showed that serum IL-2(r=0.29,P<0.01),IL-4(r=0.20,P=0.03)and IL-17(r=0.21,P=0.02)levels were positively correlated with the scores of HAMD item 3“suicide”.Creatinine levels were negatively correlated with the scores of HAMD item 3"suicide"(r=-0.22,P=0.02).Conclusion:The serum inflammatory factors and creatinine of depression patients with suicidal ideation are dif-ferent from those without suicidal ideation,and the above factors have a certain correlation with the severity of suicide.

关 键 词：抑郁症 自杀观念 炎症因子 

分 类 号：R749.4[医药卫生—神经病学与精神病学]