力学增强且降解延缓的编织型丝素纤维人工韧带材料研究  

Braided silk fibroin fiber artificial ligaments with reinforced mechanical properties and delayed degradation

作　　者：万玥 刘影 王玥 姜博宸 刘明洁 王璐[1,2] 关国平[1,2] WAN Yue;LIU Ying;WANG Yue;JIANG Bochen;LIU Mingjie;WANG Lu;GUAN Guoping(College of Textiles,Ministry of Education,Donghua University,Shanghai 201620,China;Key Laboratory of Textile Science&Technology,Ministry of Education,Donghua University,Shanghai 201620,China)

机构地区：[1]东华大学.纺织学院,上海201620 [2]东华大学纺织面料技术教育部重点实验室,上海201620

出　　处：《东华大学学报（自然科学版）》2024年第1期1-10,共10页Journal of Donghua University(Natural Science)

基　　金：高等学校学科创新引智计划(BP071935);人工韧带国家重点研发计划(2018YFC1106200)。

摘　　要：针对人工韧带产品在临床应用中存在的问题,如不可降解、应力遮挡、中远期疲劳松弛、慢性炎症等,研究力学性能优良的可降解人工韧带材料是新的发展方向。以丝素纤维为原材料,设计并制备了一种“壳芯”结构的人工韧带原型材料(artificial ligament, AL),并以负载纳米羟基磷灰石(hydroxyapatite, Hap)的聚氨酯(polyurethane, PU)溶液对AL进行涂层得到人工韧带材料(coated artificial ligament, CAL),并对CAL的形态结构、显微结构、力学性能、降解性能、细胞和组织相容性等进行了系统表征。研究结果表明:“壳芯”结构的CAL结构规整、表面平整、孔隙均匀。相较于AL,CAL的力学性能得到了显著提高(P<0.05),且体外降解速率明显延缓。此外,CAL的细胞及组织相容性良好,炎症反应低。该项研究可为开发新型高强可降解人工韧带产品提供理论依据及实践参考。Artificial ligament products exhibit various drawbacks show several shortcomings in clinical applications,including such as non-degradability,stress shielding,mid-and-to long-term fatigue relaxation,and chronic inflammation,etc.Therefore,the development of biodegradable artificial ligament materials with excellent mechanical properties represents the future direction of new-generation artificial ligaments.In the present study,an artificial ligament(AL)prototype with“shell-core”structure was designed and braided using through the use of silk fibroin fibers as raw materials,and AL was coated with polyurethane(PU)solution mixed with nano-hydroxyapatite(Hap)to obtain coated artificial ligament(CAL)materials.Moreover Furthermore,morphology,microstructure,mechanical properties,degradability,cell and tissue compatibility of the CAL were systematically characterized.The results demonstrate a regular“shell-core”structure,smooth surface,and uniform pores.show that the"shell-core"structure is regular,the surface is smooth,and the pores are uniform.Compared with to AL,the mechanical properties of the CAL were significantly improved(P<0.05),and the degradation rate in vitro was significantly delayed.Furthermore,the results of cell and tissue compatibility tests indicate that the cell and tissue compatibility of the CAL was satisfying,and the inflammatory reaction was mild CAL exhibits satisfactory cell and tissue compatibility,and mild inflammatory reaction.This study It is expected that this study can provides a theoretical basis and practical reference for development of new high-strength biodegradable artificial ligament products.

关 键 词：人工韧带 丝素纤维 编织 可降解 力学性能 

分 类 号：TS101.4[轻工技术与工程—纺织工程]