静脉滴注奥沙利铂致急性神经毒性2例  

2 cases of acute neurotoxicity caused by intravenous infusion of oxaliplatin

作　　者：贺闺连 张家豪 HE Gui-lian;ZHANG Jia-hao(Department of Oncology,Jiangxi Province Hospital of Integrated Chinese and Western Medicine,Nanchang 330003,China)

机构地区：[1]江西省中西医结合医院肿瘤科,330003 [2]广东省中医院肿瘤科,510030

出　　处：《中国现代药物应用》2024年第3期144-146,共3页Chinese Journal of Modern Drug Application

摘　　要：奥沙利铂是第三代铂类抗癌药物,与其他铂类化疗药物相比,在胃肠道肿瘤上体现的特异性抗肿瘤活性更明显。其中神经毒性反应是常见的不良反应,它具有独特的临床表现,其发生机制至今尚不完全清楚,且缺乏标准有效的防治方法。本文通过对2例奥沙利铂所致急性神经毒性病例进行分析,探究出现神经毒性的因素以及减少神经毒性发生的防治方法。Oxaliplatin is a third-generation platinum-based anticancer drug.Compared with other platinum-based chemotherapy drugs,oxaliplatin has more specific anti-tumor activity in gastrointestinal tumors.Neurotoxic reaction is a common adverse reaction,it has a unique clinical manifestations,its mechanism is not completely clear,and there is a lack of standard effective prevention and treatment methods.In this paper,2 cases of acute neurotoxicity induced by oxaliplatin are analyzed to explore the factors of neurotoxicity and the prevention and treatment methods to reduce the occurrence of neurotoxicity.

关 键 词：奥沙利铂 急性神经毒性 不良反应 

分 类 号：R969[医药卫生—药理学]