β-内酰胺类抗生素对临床早产儿血清IL-10、IL-4、IFN-γ的影响  

Effects of β-lactam antibiotics on serum IL-10,IL-4,IFN-γ in clinical premature infants

作　　者：陈培培[1] 郑芬[1] 邱世洁 郑佩榆 曾旺 CHEN Pei-pei;ZHENG Fen;QIU Shi-jie(Foshan Maternal and Child Health Care Hospital,Guangdong Foshan 528000)

机构地区：[1]佛山市妇幼保健院检验科,广东佛山528000 [2]佛山市妇幼保健院科教科,广东佛山528000 [3]佛山市妇幼保健院新生儿科,广东佛山528000

出　　处：《医学检验与临床》2023年第11期11-14,共4页Medical Laboratory Science and Clinics

基　　金：佛山市卫生健康局医学科研课题,项目编号:20220421。

摘　　要：目的:探讨β-内酰胺类抗生素对临床早产儿血清白介素-4(IL-4)、白介素-10(IL-10)、γ干扰素(IFN-γ)等指标的影响.方法:选取2022年1月-2022年12月本院新生儿科的70例感染患儿为研究对象,按照患儿出生胎龄分组,其中出生胎龄在28~37周的新生儿编入早产儿组(n=40)、足月妊娠的新生儿编入对照组(n=30).两组患儿临床均使用了 β-内酰胺类抗生素治疗,比较两组患儿血清IL-4、IL-10、IFN-γ指标水平及异常率,同时分析药物对患儿免疫球蛋白IgA、IgM、IgG指标水平的影响,最后对比两组患儿的不良反应发生情况.结果:治疗前两组患儿的血清IL-4、IL-10、IFN-γ对比差异不显著(P>0.05);治疗后两组患儿的IL-4、IL-10、IFN-γ均呈现下降的状态,且早产儿组指标水平高于对照组(P<0.05).治疗后早产儿组患儿IL-4、IL-10、IFN-γ异常率高于对照组,对比差异显著(P<0.05).治疗前两组IgA、IgM、IgG指标对比差异不显著(P>0.05);治疗后两组患儿的IgA、IgM、IgG对比差异不显著(P>0.05).早产儿组患儿不良反应发生率高于对照组,对比差异不显著(P>0.05).结论:β-内酰胺类抗生素在治疗早产儿感染患儿中对其机体炎性反应控制有一定积极作用,但作用效果不如足月儿;同时β-内酰胺类抗生素的安全性基本能够保障,不会引起体液免疫水平的异常改变,不良反应发生率也较低,可满足早产儿感染患儿的治疗需要.Objective:To examine the effects ofβ-lactam antibiotics on serum interleukin-4(IL-4),interleukin-10(IL-10)and Interferon-(IFN-).Methods:70 infected children in the neonatal department of our hospital from January 2022 to December 2022 were selected as the research subjects.Grouping according to the gestational age of the child,newborns born between 28 and 37 weeks of gestational age were included in the preterm group(n=40),and newborns born at term were included in the control group(n=30).Both groups of children were treated withβ-lactam antibiotics.The serum IL-4,IL-10,IFN-γand abnormal rate between two groups of children were compared.The impacts of drugs on immunoglobulin IgA,IgM and IgG in children were analyzed.In addition,the incidence ofadverse reactions between the two groups of children was compared.Results:There was no signifcant diference in serum IL-4,IL-10 and IFN-γbetween the two groups of children before treatment.IL-4,IL-10 and IFN-γ of two groups of children both showed a decreasing state after treatment,and the values in the premature group were higher than those in the control group(P<0.05).After treatment,the abnormal rate of premature infants in the group was higher than that in the control group(P<0.05).There was no significant difference of IgA、IgM and IgG between the two groups before and after treatment(P≥0.05).The incidence of adverse reactions in premature infants was higher than that in the control group(P>0.05).Conclusion:β-lactam antibiotics play a positive role in the control of inflammatory reaction in the treatment of infected preterm infants,but the effect is not as effective as that of term infants.Meanwhile,β-lactam antibiotics will not cause abnormal changes in humoral immunity.The incidence of adverse reactions is low,which can meet the treatment needs of infected children of premature infants.

关 键 词：早产儿 抗菌治疗 Β-内酰胺类 血清炎性因子 安全性 

分 类 号：R446.11[医药卫生—诊断学]