血清vaspin水平与急性脑梗死患者病情严重程度、预后情况及炎性因子的相关性  

Correlation between serum vaspin level and severity,prognosis and inflammatory factors in patients with acute cerebral infarction

作　　者：张丽[1] 汤小利[1] 杨收平[2] 李海英[3] ZHANG Li;TANG Xiao-li;YANG Shou-ping(Department of clinical laboratory medicine,The first people's hospital of Lianyungang,Jiangsu Lianyungang 222000)

机构地区：[1]连云港市第一人民医院检验科,江苏连云港222000 [2]连云港市东方医院普通内科,江苏连云港222042 [3]连云港市东方医院检验科,江苏连云港222042

出　　处：《医学检验与临床》2024年第1期29-32,共4页Medical Laboratory Science and Clinics

摘　　要：目的:探讨急性脑梗死(ACI)患者血清vaspin水平的变Lianyungang重程度、预后状况及炎性因子的相关性。方法:ACI患者105例,根据不同卒中程度分为轻度卒中组、中度卒中组、重度卒中组3组,同时按预后情况分成预后良好组、预后不良组。取同期健康体检者34例作为健康对照组。采用ELISA法测定血清vaspin水平,同时测定白细胞介素-6(IL-6)、超敏C反应蛋白(hsCRP)及其他生化指标,并做统计学处理。结果:ACI组vaspin水平显著低于健康对照组,IL-6、hsCRP显著高于健康对照组,差异有统计学意义(P<0.01);重度卒中组vaspin水平低于轻度卒中组、中度卒中组,IL-6、hsCRP水平高于轻度卒中组、中度卒中组;中度卒中组vaspin水平低于轻度卒中组,IL-6、hsCRP水平高于轻度卒中组,差异有统计学意义(P<0.01);Spearman相关分析显示,ACI组血清vaspin与FBG、FINS、HOMA-IR、TG、LDL-C、IL-6、hsCRP呈负相关,r值分别为(-0.409、-0.341、-0.305、-0.286、-0.357、-0.415、-0.388,P<0.05),与BMI、HDL-C呈正相关,r值分别为(0.459、0.375,P<0.05),与年龄、BSP、HSP无相关性(P>0.05)。结论:ACI患者血清vaspin水平降低,且与患者卒中程度、预后情况以及炎性因子IL-6、hsCRP表达水平具有相关性。Vaspin可以作为判断患者病情严重程度、预后评估的依据。Objective:To investigate the relationship between serum vaspin level and severity,prognosis and inflammatory factors in patients with acute cerebral infarction(ACI).Methods:105 patients with ACI were divided into 3 groups:mild stroke group,moderate stroke group and severe stroke group according to the degree of stroke.Thirty-four healthy persons were selected as control group.The serum levels of vaspin,IL-6,HSCRP and other biochemical IL-6 were measured by Elisa.Results:The levels of vaspin in ACI Group were significantly lower than those in healthy control group,and the levels of IL-6 and HSCRP in ACI Group were significantly higher than those in healthy control group(P<0.01),the levels of Vaspin in moderate stroke group were lower than those in mild stroke group,and the levels of IL-6 and HSCRP in moderate stroke group were higher than those in mild stroke group(P<0.01),in ACI Group,serum vaspin was negatively correlated with FBG,FINS,HOMA-IR,TG,LDL-C,IL-6,HSCRP(R=-0.409,-0.341,-0.305,-0.286,-0.357,-0.415,-0.388,P<0.05),and positively correlated with BMI and HDL-C,the R values were(0.459,0.375,P<0.05),and had no correlation with age,BSP and HSP(P>0.05).Conclusion:The serum level of vaspin is decreased in patients with ACI,and it is correlated with the degree of stroke,the prognosis,the expression of IL-6 and HSCRP.Vaspin can be used to judge the severity of the disease and evaluate the prognosis.

关 键 词：急性脑梗死 VASPIN IL-6 HSCRP 

分 类 号：R542.22[医药卫生—心血管疾病]