NLR、PLR、LMR、MPR及CMV-IgM联合检测在诊断婴幼儿巨细胞病毒感染中的临床意义  

Clinical significance of combined detection of NLR,PLR,LMR,MPR,and CMV-IgM in the diagnosis of cytomegalovirus infection in infants and young children

作　　者：周海金 谭育青 刘青青 ZHOU Hai-jin;TAN Yu-qing;LIU Qing-qing(Laboratory Department of Zhuzhou Maternal and Child Health Hospital,Hunan Zhuzhou 412000)

机构地区：[1]株洲市妇幼保健院检验科,湖南株洲412000

出　　处：《医学检验与临床》2024年第1期33-36,42,共5页Medical Laboratory Science and Clinics

摘　　要：目的:探讨中性粒细胞与淋巴细胞比值(NLR)、血小板与淋巴细胞比值(PLR)、淋巴细胞与单核细胞比值(LMR)、平均血小板体积与血小板计数比值(MRP)及巨细胞病毒特异抗体(CMV-IgM)联合检测在诊断婴幼儿巨细胞病毒(CMV)感染中的临床价值。方法:选取150例我院2020年1月-2022年12月收治的CMV感染婴幼儿作为观察组,另选取同期健康婴幼儿60例作为对照组。所有婴幼儿均采血做血常规检测,获得NLR、PLR、LMR、MPR,并检测血清CMV-IgM。比较两组NLR、PLR、LMR、MPR及CMV-IgM水平差异;绘制ROC曲线,分析NLR、PLR、LMR、MPR及CMV-IgM联合检测识别婴幼儿CMV感染的临床价值。结果:观察组血清NLR、PLR、LMR水平为(0.29±0.05)、(45.41±4.12)、(7.85±1.24),低于对照组的(0.55±0.11)、(69.87±6.12)、(5.14±1.02),MPR及CMV-IgM水平为(0.41±0.12)、(23.65±2.42)AU/mL,高于对照组的(0.22±0.05)、(10.22±1.23)AU/mL,差异有统计学意义(P<0.05);绘制ROC曲线显示,血清NLR、PLR、LMR、MPR、CMV-IgM及联合检测诊断婴幼儿CMV感染的曲线下面积分别为:0.802、0.763、0.786、0.799、0.850、0.950。结论:NLR、PLR、LMR、MPR及CMV-IgM联合检测在婴幼儿CMV诊断中价值高,可提高诊断灵敏度、特异度,可减少漏诊、误诊风险,便于早期开展治疗工作,保障患儿健康成长。Objective:To explore the clinical value of combined detection of neutrophil to lymphocyte ratio(NLR),platelet to lymphocyte ratio(PLR),lymphocyte to Monocyte ratio(LMR),mean platelet volume to platelet count ratio(MRP)and cytomegalovirus specific antibody(CMV IgM)in the diagnosis of cytomegalovirus(CMV)infection in infants.Methods:150 infants and young children with CMV infection admitted to our hospital from January 2020 to December 2022 were selected as the observation group,and 60 healthy infants and young children in the same period were selected as the control group.All infants and young children were collected for blood routine testing to obtain NLR,PLR,LMR,MPR,and serum CMV-IgM.Compare the differences in NLR,PLR,LMR,MPR,and CMV-IgM levels between the two groups;Draw Receiver operating characteristic and analyze the clinical value of combined detection of NLR,PLR,LMR,MPR and CMV IgM to identify infant CMV infection.The serum levels of NLR,PLR,and LMR in the observation group were(0.29±0.05),(45.41±4.12)and(7.85±1.24),which were lower than those in the control group(0.55±0.11),(69.87±6.12)and(5.14±1.02).The levels of MPR and CMV-IgM were(0.41±0.12),(23.65±2.42)AU/mL,which were higher than those in the control group(0.22±0.05),(10.22±1.23)AU/mL,and the difference was statistically significant(P<0.05);The Receiver operating characteristic showed that the area under the curve of serum NLR,PLR,LMR,MPR,CMV IgM and combined detection for diagnosis of infant CMV infection were 0.802,0.763,0.786,0.799,0.850 and 0.950,respectively.Conclusion:The combined detection of NLR,PLR,LMR,MPR and CMV-IgM has high value in the diagnosis of CMV in infants and young children.It can improve diagnostic sensitivity and specificity,reduce the risk of missed diagnosis and misdiagnosis,facilitate early treatment work,and ensure the healthy growth of children.

关 键 词：婴幼儿巨细胞病毒感染 中性粒细胞与淋巴细胞比值 血小板与淋巴细胞比值 巨细胞病毒特异抗体 

分 类 号：R446[医药卫生—诊断学]