Rh系统抗-D与抗-E抗体共同致新生儿溶血病的研究分析  

The research and analysis of hemolytic disease of new born causing by anti-D with anti-E in Rh system

作　　者：吴晓春 姜坤 于晓梅 孙福廷[1] WU Xiao-chun;JIANG Kun;YU Xiao-mei(Weifang People's Hospital,Shandong Weifang 261041)

机构地区：[1]潍坊市人民医院输血科,山东潍坊261041

出　　处：《医学检验与临床》2024年第1期46-50,共5页Medical Laboratory Science and Clinics

摘　　要：目的:研究1例Rh系统2种不规则抗体(抗-D、抗-E)同时存在导致新生儿溶血病。方法:通过临床资料提供,对产妇进行血型分析,不规则抗体筛查及抗体特异性鉴定,抗体效价分析;对新生儿进行直接抗人球蛋白试验、游离试验、放散试验及抗体特异性分析。结果:产妇不规则抗体阳性,抗体为Rh系统抗-D与抗-E,IgG抗-D效价为512,IgG抗-E效价为2;新生儿直接抗人球蛋白试验阳性、放散试验检出抗-D和抗-E抗体,游离试验检出抗-D抗体。结论:经新生儿三项实验诊断新生儿溶血病成立,积极给予对症治疗,患儿康复出院。Objective:To investigated one case of hemolytic disease of the new born caused by simultaneous of two irregular antibodies(anti-D and anti-E)in Rh system.Methods:Provided by clinical data,After blood group identification and irregular antibody screening of pregnant woman,determining titer of antibody by means of immunoserology;Direct antiglobulin test,antibody release test,free antibody test and further antibody identification conducting for the new born.Results:The irregular antibody is positive combining anti-D with anti-E in Rh system,the IgG titer of antibody was 512 and 2;Direct antiglobulin test is positive,antibody release test appearing anti-D and anti-E,anti-D presented in free antibody test.Conclusion:The diagnosis of hemolytic disease of new born was established and the child recovery discharged from hospital smoothly gived by symptomatic treatment actively.

关 键 词：新生儿溶血病 RHD阴性 抗-D 抗-E 

分 类 号：R722.18[医药卫生—儿科]