替罗非班对急性ST段抬高型心肌梗死患者内皮素-1水平及凝血功能的影响  

Effects of tirofiban on endothelin-1 level and coagulation function in patients with acute ST-segment elevation myocardial infarction

作　　者：毕旋律 林凡力 李丹丹 张亚军 王彩羽 郭莎 BI Xuanlv;LIN Fanli;LI Dandan;ZHANG Yajun;WANG Caiyu;GUO Sha(Cardiovascular Internal Medicine Department,General Nanyang Oil Field Hospital,Nanyang 473132,China)

机构地区：[1]河南省南阳市宛城区官庄镇南阳油田总医院心血管内科,河南南阳473132

出　　处：《临床医学研究与实践》2024年第6期55-58,共4页Clinical Research and Practice

摘　　要：目的探讨替罗非班对急性ST段抬高型心肌梗死患者内皮素-1(ET-1)水平及凝血功能的影响。方法选取2021年1月至2023年1月我院收治的92例急性ST段抬高型心肌梗死患者,采用随机数字表法将其分为对照组(n=46)和观察组(n=46)。对照组采用瑞替普酶溶栓治疗,观察组在对照组基础上加用替罗非班治疗。比较两组的治疗效果。结果观察组的治疗总有效率为95.65%,高于对照组的82.61%(P<0.05)。治疗后,两组的左心室收缩末期内径(LVESD)、左心室舒张末期内径(LVEDD)均降低,左心室射血分数(LVEF)、心搏出量(SV)均升高,且观察组优于对照组(P<0.05)。治疗后,两组的凝血酶时间(TT)、凝血酶原时间(PT)、活化部分凝血酶时间(APTT)均延长,且观察组长于对照组(P<0.05)。治疗后,两组的白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)水平均明显降低,且观察组低于对照组(P<0.05)。治疗后,两组的ET-1水平均明显降低,一氧化氮(NO)水平均明显升高,且观察组优于对照组(P<0.05)。结论替罗非班治疗急性ST段抬高型心肌梗死患者的效果确切,可改善患者的心功能、凝血功能及内皮功能,值得临床推广和应用。Objective To investigate the effects of tirofiban on endothelin-1(ET-1)level and coagulation function in patients with acute ST-segment elevation myocardial infarction.Methods A total of 92 patients with acute ST-segment elevation myocardial infarction admitted in our hospital from January 2021 to January 2023 were selected and divided into control group(n=46)and observation group(n=46)by random number table method.The control group was treated with reteplase thrombolytic therapy,and the observation group was treated with tirofiban on the basis of the control group.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was 95.65%,which was higher than 82.61%in the control group(P<0.05).After treatment,the left ventricular end-systolic diameter(LVESD)and left ventricular end diastolic diameter(LVEDD)of the two groups decreased,the left ventricular ejection fraction(LVEF)and stroke volume(SV)increased,and those in the observation group were better than the control group(P<0.05).After treatment,the thrombin time(TT),prothrombin time(PT)and activated partial thromboplastin time(APTT)of the two groups prolonged,and those in the observation group were longer than the control group(P<0.05).After treatment,the levels of interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)and C-reactive protein(CRP)in the two groups significantly decreased,and those in the observation group were lower than the control group(P<0.05).After treatment,the level of ET-1 in the two groups significantly decreased,and the level of nitric oxide(NO)significantly increased,and those in the observation group were better than the control group(P<0.05).Conclusion Tirofiban in the treatment of patients with acute ST-segment elevation myocardial infarction has exact effect,it can improve the cardiac function,coagulation function and endothelial function of patients,whick is worthy of clinical promotion and application.

关 键 词：替罗非班 急性ST段抬高型心肌梗死 内皮素-1 凝血功能 

分 类 号：R542.22[医药卫生—心血管疾病]