FAPI PET/CT在消化道肿瘤诊断中的研究进展  

The research progress of FAPI PET/CT in the diagnosis of gastrointestinal tumors

作　　者：金景国 王志强[1] 孙卫军[1] 徐慧[1] 章万乐 JIN Jingguo;WANG Zhiqiang;SUN Weijun;XU Hui;ZHANG Wanle(Department of Nuclear Medicine,the First Affiliated Hospital of Wenzhou Medical University,Wenzhou 325015,China)

机构地区：[1]温州医科大学附属第一医院核医学科,浙江温州325015

出　　处：《温州医科大学学报》2024年第2期158-164,共7页Journal of Wenzhou Medical University

摘　　要：核医学放射性药物是一种利用放射性同位素标记化合物作为特定生物或器官成像和治疗的工具。同位素标记的成纤维细胞活化蛋白抑制剂(FAPI)是一种新型的放射性药物,具有高灵敏度和特异度,能够提供高分辨率的图像,准确检测和定位肿瘤,评估其生长和转移情况,以及检测治疗效果;并且能提供关于肿瘤组织的详细信息,有助于制定个体化治疗方案,已被广泛研究和应用于多种癌症的诊断和治疗。笔者将介绍FAPI的特点及FAPI PET/CT在消化道肿瘤中的应用,并比较其和18F-FDG PET/CT在消化道肿瘤诊断中的优劣情况,以进一步说明FAPI在消化道肿瘤中的应用价值。Nuclear medicine radiopharmaceuticals is a type of compound labeled with radioisotopes as a tool for imaging and treatment of specific biology or organs.Isotope labeled fibroblast activation protein inhibitor(FAPI)is a new type of radiopharmaceutical with high sensitivity and specificity,capable of providing highresolution images,accurately detecting and locating tumors,evaluating their growth and metastasis,and detecting therapeutic effects.Widely studied and used in the diagnosis and treatment of various cancers,it can provide detailed information about tumor tissues and help to develop treatment plan for the individuals.In this review,we will introduce the characteristics of FAPI and its application in gastrointestinal tumors,and compare its advantages and disadvantages with 18F-FDG PET/CT in cancer diagnosis to further illustrate the clinical value of FAPI in gastrointestinal tumors.

关 键 词：消化道肿瘤 成纤维细胞活化蛋白抑制剂 氟脱氧葡萄糖F18 正电子发射断层显像术 

分 类 号：R817.4[医药卫生—影像医学与核医学]