脂代谢异常人群亚临床甲状腺功能减退患病率及相关因素研究  

Study on the Prevalence and related Factors of subclinical Hypothyroidism in Individuals with abnormal Lipid Metabolism

作　　者：陈秀勤[1] 蒙秀坚 莫石贤 邱永佳 CHEN Xiuqin;MENG Xiujian;MO Shixian;QIU Yongjia(Department of Laboratory,Wuzhou Red Cross Hospital,Wuzhou Guangxi 543000,China;Department of Blood Transfusion,The Seventh Affiliated Hospital of Guangxi Medical University,Wuzhou Guangxi 543000,China;Department of Laboratory,Wuzhou People's Hospital,Wuzhou Guangxi 543000,China)

机构地区：[1]梧州市红十字会医院检验科,广西梧州543000 [2]广西医科大学第七附属医院输血科,广西梧州543000 [3]梧州市人民医院检验科,广西梧州543000

出　　处：《临床研究》2024年第3期1-4,共4页Clinical Research

摘　　要：目的探讨脂代谢异常人群亚临床甲状腺功能减退(SCH)患病率及相关因素。方法选择梧州市红十字会医院2018年1月至2022年12月收入的3650例脂代谢异常人群,分析SCH患病率,对SHC患者和非SCH患者的临床资料进行对比,将有差异项目带入Logistic回归方程计算,分析其对脂代谢异常人群患SCH的影响。结果脂代谢异常人群中SCH患者962例,患病率26.36%;对SCH患者及非SCH患者一般资料进行单因素Logistic回归分析发现性别、身体质量指数(BMI)、甘油三酯(TG)、舒张压(DP)、抗甲状腺球蛋白抗体(TgAb)、收缩压(SP)、年龄、空腹血浆葡萄糖(FBG)、低密度脂蛋白(LDL-C)、负荷后2 h血糖(2hPG)、总胆固醇(TC)、高密度脂蛋白(HDL-C)、谷草转氨酶(AST)、血钙、血磷、血尿酸(UA)、抗甲状腺过氧化物酶抗体(TPOAb)在两组中差异有统计学意义(P<0.05);不同种类脂代谢异常以高TG血症居多,差异有统计学意义(P<0.05),而脂代谢异常人群SCH患病率混合高脂血症最高,差异有统计学意义(P<0.05);将以上对比有差异的影响因素进行多因素Logistic回归分析发现性别、年龄、SP、TC、FBG、2hPG均为影响脂代谢异常人群患SCH的独立因素。结论脂代谢异常与SCH疾病发生之间有紧密联系,患病情况在女性、高龄患者中更突出,血脂可能在一定程度上影响甲状腺激素的分泌,最终引发SCH,因此临床需重视相关因素并进行防治。Objective To explore the prevalence and related factors of subclinical hypothyroidism(SCH)in individuals with abnormal lipid metabolism.Methods A total of 3650 individuals with abnormal lipid metabolism who were admitted to the Red Cross Hospital of Wuzhou City from January 2018 to December 2022 were selected to analyze the incidence of SCH.Clinical data of SHC patients and non-SCH patients were compared,and the differences were calculated using the logistic regression equation to analyze their impact on the incidence of SCH in the population with abnormal lipid metabolism.Results Among the population with abnormal lipid metabolism,there were 962 patients with SCH,with a prevalence rate of 26.36%;Univariate Logistic regression analysis showed that there were significant differences in sex,body mass index(BMI),triglyceride(TG),diastolic blood pressure(DP),antithyroglobulin antibody(TgAb),systolic blood pressure(SP),age,fasting blood glucose(FBG),low-density lipoprotein(LDL-C),2h post load plasma glucose(2hPG),total cholesterol(TC),high-density lipoprotein(HDL-C),aspartate transaminase(AST),serum calcium,phosphorus,uric acid(UA)and thyroid peroxidase antibody(TPOAb)between the SCH and non-SCH patients(P<0.05).Different types of lipid metabolism abnormalities are mainly characterized by hypertriglyceridemia,with statistically significant differences(P<0.05).The population with lipid metabolism abnormalities has the highest incidence of SCH mixed with hyperlipidemia,with statistically significant differences(P<0.05);Multivariate logistic regression analysis was conducted on the influencing factors with differences in the above comparison,and it was found that gender,age,SP,TC,FBG,and 2hPG were all independent factors affecting the incidence of SCH in individuals with abnormal lipid metabolism.Conclusion There is a close relationship between abnormal lipid metabolism and the occurrence of SCH disease,which is more prominent in female and elderly patients.Blood lipids may affect the secretion of thyroid hormones to a c

关 键 词：脂代谢异常 亚临床甲状腺功能减退 血脂 血糖 甲状腺激素 

分 类 号：R581.2[医药卫生—内分泌]