抗感颗粒联合利巴韦林治疗小儿手足口病患者的效果分析  

Analysis of the Effect of Anti-Sense Granules Combined with Ribavirin in the Treatment of Children with Hand,Foot,and Mouth Disease

作　　者：张贵州 ZHANG Guizhou(Comprehensive Treatment Room,Nanyang City Central Hospital,Nanyang Henan 473000 China)

机构地区：[1]南阳市中心医院综合治疗室,河南南阳473000

出　　处：《临床研究》2024年第3期89-92,共4页Clinical Research

摘　　要：目的分析抗感颗粒+利巴韦林对小儿手足口病(HFMD)的疗效及对患者免疫功能和炎症因子的影响。方法选取南阳市中心医院2021年1月至2023年1月收治的76例HFMD患儿作为研究对象,依据区间随机法将其分为对照组、研究组,各38例,对照组单纯使用利巴韦林治疗,研究组使用析抗感颗粒+利巴韦林治疗。比较两组治疗有效率,基础症状消失时间,治疗前后炎性因子指标[C反应蛋白(CRP)、降钙素原(PCT)、白细胞介素6(IL-6)、肿瘤坏死因子α(TNF-α)]及免疫功能指标[免疫球蛋白A(IgA)、免疫球蛋白G(IgG)、免疫球蛋白M(IgM)]。结果研究组治疗有效率显著高于对照组,研究组疱疹恢复时间、体温恢复时间、口腔溃疡消退时间、食欲恢复时间均显著短于对照组;治疗前,组间各炎症因子水平对比,差异无统计学意义(P>0.05),治疗后,两组CRP、PCT、TNF-α、IL-6均较治疗前明显降低,且研究组显著低于对照组,差异有统计学意义(P<0.05);治疗前,两组各项免疫功能指标水平对比,差异无统计学意义(P>0.05),治疗后,两组IgA、IgG、IgM水平均明显升高,且研究组显著高于对照组,差异有统计学意义(P<0.05)。结论对比单一利巴韦林治疗,抗感颗粒+利巴韦林联合治疗HFMD疗效更理想,可提升患儿免疫功能,降低机体炎症因子水平,值得应用。Objective To analyze the efficacy of anti-sense granules+ribavirin on hand,foot,and mouth disease(HFMD)in children and its impact on the patient’s immune function and inflammatory factors.Methods 76 children with HFMD admitted to Nanyang City Central Hospital from January 2021 to January 2023 were selected as the research subjects.According to the interval random method,they were divided into a control group and a research group,each with 38 cases.The control group was treated with ribavirin alone,and the research group was treated with anti-sense granules+ribavirin.Compare the effective rate of the two groups,the disappearance time of basic symptoms,the inflammatory factor indicators before and after treatment[C-reactive protein(CRP),procalcitonin(PCT),interleukin 6(IL-6),tumor necrosis factorα(TNF-α)]and immune function indicators[immunoglobulin A(IgA),immunoglobulin G(IgG),immunoglobulin M(IgM)].Results The effective rate of the research group was significantly higher than that of the control group.The recovery time of herpes,body temperature,oral ulcers,and appetite in the research group were significantly shorter than those in the control group;before treatment,the comparison of various inflammatory factor levels between the two groups showed no statistical significance(P>0.05).After treatment,the levels of CRP,PCT,TNF-α,and IL-6 in both groups were significantly lower than before treatment,and the research group was significantly lower than the control group,with statistically significant differences(P<0.05);before treatment,the comparison of various immune function indicators between the two groups showed no statistical significance(P>0.05).After treatment,the levels of IgA,IgG,and IgM in both groups were significantly increased,and the research group was significantly higher than the control group,with statistically significant differences(P<0.05).Conclusion Compared with single ribavirin treatment,the combined treatment of anti-sense granules+ribavirin for HFMD is more ideal,can enhance the immune f

关 键 词：抗感颗粒 利巴韦林 小儿手足口病 免疫功能 炎症因子 

分 类 号：R392.3[医药卫生—免疫学]