茯神裂环羊毛甾烷型化学成分研究  

Seco-lanostane constituents from Poria cum Pini Radix

作　　者：邓子怡 郁阳 李莉[2] 杨财子 孙云鹏 王国凯 刘劲松 DENG Zi-yi;YU Yang;LI Li;YANG Cai-zi;SUN Yun-peng;WANG Guo-kai;LIU Jinsong(College of Pharmacy,Anhui University of Chinese Medicine,Hefei 230012;Institute of Integrated Traditional Chinese and Western Medicine,Anhui University of Chinese Medicine,Hefei 230012;Anhui Key Laboratory of Research&Development of Chinese Medicine,Hefei 230012;Key Laboratory for Functional Substances in Chinese Medicine and Natural Medicine,Hefei 230012)

机构地区：[1]安徽中医药大学药学院,合肥230012 [2]安徽中医药大学中西医结合学院,合肥230012 [3]中药研究与开发安徽省重点实验室,合肥230012 [4]中药功效物质组分校级重点实验室,合肥230012

出　　处：《中南药学》2024年第2期404-408,共5页Central South Pharmacy

基　　金：安徽中医药大学探索性科研项目(No.2020HXTS09);安徽高等学校科学研究重点项目(No.2022AH050489)。

摘　　要：目的研究茯神中裂环羊毛甾烷型化学成分。方法应用硅胶柱色谱、RP-18中压柱色谱、Sephadex LH-20葡聚糖凝胶、半制备HPLC等分离手段进行分离纯化,所获得的单体化合物经核磁共振波谱和质谱数据鉴定。结果从茯神中分离鉴定出11个裂环羊毛甾烷类单体化合物,分别为茯苓新酸B(1)、茯苓新酸A(2)、茯苓新酸DM(3)、16α,27-二羟基-3,4-裂环羊毛甾-4(28),8(9),24-三烯-3,21-二酸(4)、茯苓新酸ZC(5)、茯苓新酸ZM(6)、茯苓新酸E(7)、茯苓新酸D(8)、茯苓新酸ZG(9)、茯苓新酸M(10)、茯苓新酸L(11)。结论化合物4~6和9~11首次从茯苓的药用部位茯神中分离得到。Objective To determine the chemical constituents of seco-lanostane in Poria cum Pini Radix.Methods The seco-lanostanes were separated and purified with a variety of chromatographic techniques as silica gel column,RP-18 medium pressure column,Sephadex LH-20 column,and preparative HPLC,and identified by NMR and MS spectroscopy.Results Totally 11 seco-lanostanes were isolated from Poria cum Pini Radix,and identified as poricoic acid B(1),poricoic acid A(2),poricoic acid DM(3),16α,27-dihydroxy-3,4-secolanosta-4(28),8(9),24-triene-3,21-dioic acid(4),poricoic acid ZC(5),poricoic acid ZM(6),poricoic acid E(7),poricoic acid D(8),poricoic acid ZG(9),poricoic acid M(10)and poricoic acid L(11).Conclusion Compounds 4~6 and 9~11 have been obtained from the Poria cum Pini Radix for the first time.

关 键 词：茯神 裂环羊毛甾烷型 化学成分 结构鉴定 

分 类 号：R284[医药卫生—中药学]