非共价键构象锁策略优化半导体聚合物纳米颗粒的NIR-Ⅱ光声/光热性能用于高效光诊疗  

Noncovalent conformational lock-based molecular engineering improves NIR-II photoacoustic/photothermal performance of semiconducting polymer nanoparticles for efficient phototheranostics

作　　者：陈杨 杨光照 李平 尹黎坤 陈露 柳钰 梁昕 陈莹 尹超 范曲立 Yang Chen;Guangzhao Yang;Ping Li;Likun Yin;Lu Chen;Yu Liu;Xin Liang;Ying Chen;Chao Yin;Quli Fan(State Key Laboratory of Organic Electronics and Information Displays&Institute of Advanced Materials(IAM),Nanjing University of Posts and Telecommunications,Nanjing 210023,China)

机构地区：[1]State Key Laboratory of Organic Electronics and Information Displays&Institute of Advanced Materials(IAM),Nanjing University of Posts and Telecommunications,Nanjing 210023,China

出　　处：《Science China Materials》2023年第12期4865-4874,共10页中国科学（材料科学）（英文版）

基　　金：supported by the National Natural Science Foundation of China(62005127);the Natural Science Foundation of Jiangsu Province(BK20200751);the Project of Jiangsu Specially-Appointed Professor(RK030STP22003);the Research Startup Fund of Nanjing University of Posts and Telecommunications(NY220068);the Project of State Key Laboratory of Organic Electronics and Information Displays(ZS030ZR22014).

摘　　要：开发近红外二区(NIR-Ⅱ)响应的纳米制剂用于NIR-Ⅱ光声成像(PAI)引导的光热治疗(PTT)为推进深层组织光诊疗的发展提供了机遇.尽管半导体聚合物纳米颗粒(SPNs)在NIR-ⅡPAI和PTT中展现出巨大的应用潜力,但其有限的光声/光热效能使得实现高效的体内光诊疗仍然是一个巨大的挑战.本工作中,我们提出了一种基于非共价键构象锁(NCL)的分子工程策略来优化SPN的NIR-Ⅱ光声/光热性能,以实现高效的体内光诊疗.NCL的引入有助于改善半导体聚合物主链的平面性,增强其捕光能力,从而提高NIR-Ⅱ光声/光热信号的输出.优化出的SPN3毒性低、尺寸合适、光物理性能好,不仅能被4T1癌细胞有效摄取并在NIR-Ⅱ光激发下杀死细胞,而且经全身给药后可通过NIR-ⅡPAI点亮肿瘤轮廓,进一步指导NIR-ⅡPTT的进行以实现高效的肿瘤热消融.因此本文的研究提供了一种独特的分子设计策略来放大SPN的NIR-Ⅱ光声/光热信号,最终实现活体高效光诊疗.The development of near-infrared-II(NIR-II)-absorbing nano-agents for NIR-II photoacoustic imaging(PAI)-guided photothermal therapy(PTT)provides opportunities to advance the development of deep tissue phototheranostics.Despite the superiority of semiconducting polymer nanoparticles(SPNs)for NIR-II PAI and PTT,their limited photoacoustic/photothermal performance makes achieving effective in vivo phototheranostics still a huge challenge.In this work,we propose a noncovalent conformational lock(NCL)-based molecular engineering strategy to improve the NIR-II photoacoustic/photothermal performance of SPNs for high-efficiency phototheranostics in vivo.The introduction of NCL is favorable to improve the backbone planarity of the semiconducting polymer to enhance the lightharvesting capability,resulting in amplified NIR-II photoacoustic/photothermal output.By virtue of the low toxicity,suitable size,and improved photophysical properties,the optimal SPN3 not only can be efficiently internalized by 4T1 cancer cells to kill the cells under NIR-II light excitation but also light up the tumor profile via NIR-II PAI after systemic administration,which further guides the NIR-II PTT for efficient tumor ablation.Our investigation therefore provides a unique molecular design strategy to amplify the NIR-II photoacoustic/photothermal signals of SPNs for improved in vivo phototheranostics.

关 键 词：noncovalent conformational lock semiconducting polymer nanoparticles near-infrared-II window photoacoustic imaging photothermal therapy 

分 类 号：R318.08[医药卫生—生物医学工程] TB383.1[医药卫生—基础医学]