五味消渴方对2型糖尿病患者肠道菌群及炎症因子的影响  

Effects of Wuwei Xiaoke Fang on intestinal flora and inflammatory factors in type 2 diabetes mellitus patients

作　　者：单亮亮 姚芳[1] 叶渊渊 方水林[1] SHAN Liangliang;YAO Fang;YE Yuanyuan;FANG Shuilin(Department of Endocrine,Jiaxing Hospital of Traditional Chinese Medicine,Jiaxing 314000,Zhejiang,China)

机构地区：[1]嘉兴市中医医院内分泌科,浙江嘉兴314000

出　　处：《中国现代医生》2024年第5期73-77,共5页China Modern Doctor

基　　金：浙江省中医药科技计划项目(2022ZB345);浙江省嘉兴市科技计划项目(2019AD32236);浙江省方水林全国名老中医药专家传承工作室(国家中医药管理局人教发[2016]42号)。

摘　　要：目的探讨五味消渴方对2型糖尿病患者肠道菌群及炎症因子的影响。方法选取嘉兴市中医医院住院治疗的2型糖尿病气阴两虚证患者92例,随机分为治疗组和对照组46例。对照组采用基础治疗+二甲双胍,治疗组在对照组基础上联用五味消渴方,观察对比两组临床疗效、肠道菌群和炎症因子水平变化。结果两组患者分配均衡,基线状况良好,可比性强。治疗后,治疗组和对照组的总有效率分别为91.30%、78.26%,治疗组优于对照组(P<0.05);治疗后,治疗组患者的拟杆菌、乳杆菌以及双岐杆菌群数量均高于对照组(P<0.05);肠球菌、肠杆菌以及酵母菌群数量均低于对照组(P<0.05);治疗后,治疗组肿瘤坏死因子-α、白细胞介素-6、C反应蛋白水平降低均较对照组更明显(P<0.05)。结论五味消渴方有助于改善患者的临床症状,调节肠道菌群,降低炎症因子水平,且具有较好的安全性。Objective To explore the effect of Wuwei Xiaoke Formula on intestinal flora and inflammatory factors in patients with type 2 diabetes mellitus.Methods A total of 92 cases of type 2 diabetes patients with Qi-Yin deficiency syndrome were selected and randomly divided into treatment group(n=46)and control group(n=46).The control group was treated with basic treatment+metformin,and the treatment group was treated with Wuwei Xiaoke formula on the basis of the control group.The clinical efficacy,intestinal flora and inflammatory factor levels of the two groups were observed and compared.Results The two groups of patients were evenly distributed,with good baseline status and strong comparability.After treatment,the total effective rate of 91.30%in the treatment group was higher than that of 78.26%in the control group(P<0.05).After treatment,the number of Bacteroides,Lactobacillus and bifidobacterium groups in treatment group was higher than that in control group(P<0.05).The numbers of enterococcus,enterobacter and yeast were lower than those in control group(P<0.05).After treatment,the levels of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and C-reactive protein(CRP)in the treatment group were decreased more significantly than those in the control group(P<0.05).Conclusion Wuwei Xiaoke formula is helpful to improve the clinical symptoms of type 2 diabetes patients,regulate the disorder of intestinal flora in patients,reduce the level of inflammatory factors,and has good safety.

关 键 词：2型糖尿病 五味消渴方 肠道菌群 炎症因子 

分 类 号：R255.4[医药卫生—中医内科学]