膈下逐瘀汤联合地奥司明对大隐静脉曲张术后凝血机制的影响  

Effect of Gexia Zhuyu decoction combined with diosmin on coagulation mechanism after great saphenous varicose vein surgery

作　　者：支飞虎[1] 赵雄碧[1] 张建宇[1] 张澍漾 任园伟 ZHI Feihu;ZHAO Xiongbi;ZHANG Jianyu;ZHANG Shuyang;REN Yuanwei(Department of General Surgery,Shaoxing Hospital of Traditional Chinese Medicine,Shaoxing 321000,Zhejiang,China)

机构地区：[1]绍兴市中医院普外科,浙江绍兴321000

出　　处：《中国现代医生》2024年第4期64-67,共4页China Modern Doctor

基　　金：浙江省中医药科技计划项目(2022ZB362)。

摘　　要：目的探讨大隐静脉曲张手术患者应用膈下逐瘀汤联合地奥司明治疗对凝血机制的影响。方法选取2019年1月至2022年4月于绍兴市中医院接受大隐静脉曲张手术的60例患者,根据随机数字表法将纳入患者分为对照组和观察组,每组各30例,对照组患者予地奥司明治疗,观察组患者予地奥司明+膈下逐瘀汤治疗。比较两组患者的凝血指标、血管内皮功能、炎症因子水平。结果治疗后,观察组患者的Krüppel样转录因子、活化部分凝血活酶时间、凝血酶时间、凝血酶原时间、一氧化氮、白细胞介素(interleukin,IL)-10均显著高于对照组,纤溶酶原激活物抑制剂1型、血管性血友病因子、内皮素-1、超敏C反应蛋白、IL-2、IL-6均显著低于对照组(P<0.05)。结论膈下逐瘀汤联合地奥司明用于大隐静脉曲张术后患者可改善机体高凝状态和血管内皮功能,降低机体炎症因子水平,值得临床推广应用。Objective To investigate the effect of Gexia Zhuyu decoction combined with diosmin on coagulation mechanism in patients with great saphenous varicose vein surgery.Methods A total of 60 patients who received great saphenous varicose vein surgery in Shaoxing Hospital of Traditional Chinese Medicine from January 2019 to April 2022 were selected and divided into control group and observation group according to random number table method,with 30 patients in each group.Control group was treated with diosmin,and observation group was treated with diosmin+Gexia Zhuyu decoction.Coagulation indexes,vascular endothelial function and inflammatory factor levels were compared between two groups.Results After treatment,Krüppel-like factor 2,activated partial thromboplastin time,thrombin time,prothrombin time,nitric oxide,and interleukin(IL)-10 in observation group were significantly higher than those in control group,while plasminogen activator inhibitor type 1,von Willebrand factor,endothelin 1,hypersensitive C-reactive protein,IL-2 and IL-6 were significantly lower than those in control group(P<0.05).Conclusion Gexia Zhuyu decoction combined with diosmin can improve the hypercoagulable state and vascular endothelial function in patients with great saphenous varicose vein surgery,and reduce the level of inflammatory factors in the body,which is worth popularizing.

关 键 词：大隐静脉曲张 膈下逐瘀汤 地奥司明 凝血机制 炎症因子 

分 类 号：R654.4[医药卫生—外科学]