间苯三酚联合益气养阴汤治疗HDP对患者血清HMGB1、TAC、MDA水平及分娩结局影响  

Influences of phloroglucinol combined with Yiqiyangyin decoction for treating pregnant women with pregnancy induced hy-pertension on their levels of serum high mobility group protein-1,total antioxidant capacity and malondialdehyde,and their delivery outcomes

作　　者：阮俊霞 王成群 杨柏柳 RUAN Junxia;WANG Chengqun;YANG Bailiu(Beijing Shengbao Maternity Hospital,Beijing,100192)

机构地区：[1]北京圣宝妇产医院,100192

出　　处：《中国计划生育学杂志》2024年第2期326-331,共6页Chinese Journal of Family Planning

摘　　要：目的:分析益气养阴汤联合间苯三酚治疗妊娠期高血压(HDP)对患者血清高迁移率蛋白-1(HMGB1)、总抗氧化能力(TAC)、丙二醛(MDA)水平及分娩结局影响。方法:选取2021年1月-2022年12月本院收治的HDP患者96例,按随机数字表法分为对照组(48例,给予间苯三酚治疗)和联合组(48例,在对照组基础上给予益气养阴汤治疗)。比较两组疗效、血清HMGB1、TAC、MDA水平、脂代谢指标、血压、不良反应及分娩结局。结果:治疗后联合治疗组总有效率(95.8%)高于对照组(77.1%),两组舒张压、收缩压、平均动脉压均低于治疗前且联合组低于对照组,两组血清HMGB1、MDA水平均低于治疗前且联合组(1.85±0.47mg/L、23.56±3.56μmol/L)低于对照组(3.36±0.82 mg/L、32.47±5.16μmol/L),两组TAC水平均升高且联合组(11.26±2.65U/ml)高于对照组(9.24±2.03U/ml),两组甘油三酯、总胆固醇、低密度脂蛋白胆固醇水平均降低且联合组低于对照组,两组高密度脂蛋白胆固醇水平均上调且联合组高于对照组(均P<0.05)。联合组不良妊娠结局总发生率(8.3%)低于对照组(37.5%)(P=0.001),不良反应总发生率(6.3%)与对照组(12.5%)无差异(P=0.484)。结论:益气养阴汤联合间苯三酚治疗HDP,可更好控制患者血压水平,改善氧化应激和脂代谢水平,改善母婴结局,提高临床治疗效果,安全性好。Objective:To analyze the influences of Yiqiyangyin decoction combined with phloroglucinol for treating pregnant women with pregnancy induced hypertension(HDP)on their levels of serum high mobility group protein-1(HMGB1),total antioxidant capacity(TAC)and malondialdehyde(MDA),and their delivery outcomes.Methods:From January 2021 to December 2022,96 pregnant women with PIH were selected and were randomly divided into control group(48 cases with the treatment of phloroglucinol)and study group(48 cases with the treatment of phloro-glucinol combined with Yiqiyangyin decoction).The efficacy,the levels of serum HMGB1,TAC,MDA and the lipid metabolism indicators,the blood pressure values,the adverse reactions rate and the delivery outcomes of the women were compared between the two groups.Results:The total effective rate(95.8%)of the women in the study group af-ter treatment was significantly higher than that(77.1%)of the women in the control group.The values of diastolic blood pressure,systolic blood pressure and mean arterial pressure of the women in the two groups after treatment were significantly lower than those before treatment,and which of the women in the study group were significantly lower than those of the women in the control group.The serum levels of HMGB1 and MDA of the women in the two groups after treatment had decreased significantly,and which(1.85±0.47 mg/L and 23.56±3.56μmol/L)of the women in the study group were significantly lower than those(3.36±0.82 mg/L and 32.47±5.16μmol/L)of the women in the control group.The TAC level of the women in the two groups after treatment had increased significantly,and which(11.26±2.65 U/ml)of the women in the study group was significantly higher than that(9.24±2.03 U/ml)of the.women in the control group.The levels of triglyceride,total cholesterol and low-density lipoprotein cholesterol of the women in the two groups after treatment had decreased significantly,and which of the women in the study group were significantly lower than those of the women in the co

关 键 词：妊娠期高血压 间苯三酚 益气养阴汤高迁移率蛋白-1 总抗氧化能力 丙二醛 分娩结局 

分 类 号：R714.246[医药卫生—妇产科学]