卵泡刺激素受体基因多态性与多囊卵巢综合征关系的研究进展  

Research progress of correlation of the gene polymorphism of the follicle stimulating hormone receptor and polycystic ovary syndrome

作　　者：朱韵怡 王宇 丛晶 吴效科 马红丽 ZHU Yunyi;WANG Yu;CONG Jing;WU Xiaoke;MA Hongli(Heilongjiang University of Traditional Chinese Medicine,Harbin,Heilongjiang Province,150040;The First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine)

机构地区：[1]黑龙江中医药大学,哈尔滨150040 [2]黑龙江中医药大学附属第一医院

出　　处：《中国计划生育学杂志》2024年第2期474-479,共6页Chinese Journal of Family Planning

基　　金：2021年国家自然科学青年基金(82004403)。

摘　　要：多囊卵巢综合征(PCOS)是一种高度异质性生殖内分泌紊乱性疾病,对女性生活产生极大影响。卵泡刺激素(FSH)通过与分布在性腺上的特异性卵泡刺激素受体(FSHR)结合,起到促进和维持正常的性腺发育和生殖功能,FSHR是PCOS易感基因的位点之一。近年来,FSHR基因多态性相关研究较多,FSHR基因突变可降低FSH敏感性,雄激素水平升高,导致排卵功能障碍,影响辅助生殖等。本文对FSHR基因多态性及其对PCOS的影响进行综述,为PCOS发病风险的评估及其遗传学相关研究提供一定的理论依据。Polycystic ovary syndrome(PCOS)is a highly heterogeneous reproductive endocrine disorder,which has a great impact on the women's lives.Follicle stimulating hormone(FSH)promotes and maintains the normal gonadal de-velopment and reproductive function of the women by binding to the specific follicle stimulating hormone receptor(FSHR)distributed on the gonads,and FSHR is one of the loci of the PCOS susceptibility genes.In recent years,there have been many studies on FSHR gene polymorphism.FSHR gene mutation of the women can reduce their FSH sensitivity and increase their androgen level,so as to cause the ovulation dysfunction and to affect the assisted repro-duction of the women.In this paper,FSHR gene polymorphism and its effects on the PCOS of the women were re-viewed to provide certain theoretical basis for the risk assessment and the genetic research of PCOS.

关 键 词：多囊卵巢综合征 卵泡刺激素受体 基因多态性 相关性 

分 类 号：R711.75[医药卫生—妇产科学]