可见光诱导玫瑰红催化喹喔啉-2(1H)-酮的C3-H烷基化反应  

Visible-light-induced direct C3-H alkylation of quinoxaline-2(1H)-one derivatives using rose bengal as photocatalyst

作　　者：赵能选 徐宏烈 刘华 李兰杰 ZHAO Neng-xuan;XU Hong-lie;LIU Hua;LI Lan-jie(Zhejiang Avilive Chenmical Co.,Ltd,Jinhua 322118,China)

机构地区：[1]浙江埃森化学有限公司,浙江金华322118

出　　处：《化学研究与应用》2024年第2期331-337,共7页Chemical Research and Application

摘　　要：建立了一种简单、实用的光诱导一锅法高选择性N-甲基喹喔啉酮类化合物和苯乙酮类化合物合成一系列3-烷基化喹唑啉-2(1H)-酮类化合物的方法。该方法在室温条件下,以玫瑰红作为光催化剂,在18 W 460 nm的蓝色LED下照射8 h,通过直接C3-H活化的方案,较好收率获得一系列相应的3-烷基化喹喔啉-2(1H)-酮类化合物,最高产率可达到76%。反应体系具有经济实用性和底物适用范围广的特点,为3-烷基化喹喔啉-2(1H)-酮类化合物类化合物的合成提供了一种简便经济的方法。A simple and novel visible-light-induced one pot reaction with high selectivity had been established for the synthesis of a series of 3-alkylated quinoxaline-2(1H)-one derivatives from N-methyl-quinoxalin-2(1H)-ones and propiophenones.Through direct C3-H activation,the reaction had been achieved under mild conditions at room temperature by using rose bengal as photocatalyst,which was cheap,easy to handle and environmentally friendly.Various 3-alkylated quinoxalin-2(1H)-ones were obtained in good yields,with a maximum yield of 76%by irradiation under 18 W blue LED for 8 h.The reaction system had the characteristics of eco-nomic practicality and wide substrate applicability,providing a simple and economical method for the synthesis of 3-alkylated qui-noxaline-2(1H)-one compounds.

关 键 词：可见光 喹唑啉-2(1H)-酮 苯丙酮 3-烷基化喹唑啉-2(1H)-酮 

分 类 号：O626.4[理学—有机化学]