多种油脂肪乳剂应用于极低出生体重儿肠外营养的安全性研究  

Safety of Multi-oil Fat Emulsion in Parenteral Nutrition of Extremely Low Birth Weight Infants

作　　者：厉星[1] 姜舟 华思琪 应苗法[1] 赵蕊[1] LI Xing;JIANG Zhou;HUA Siqi;YING Miaofa;ZHAO Rui(Department of Pharmacy,Qiantang Campus,Sir Run Run Shaw Hospital,College of Medicine,Zhejiang University,Hangzhou 310018,China;Department of Neonatal Intensive Care Unit,Qiantang Campus,Sir Run Run Shaw Hospital,College of Medicine,Zhejiang University,Hangzhou 310018,China;School of Pharmacy,Hangzhou Medical College,Hangzhou 311399,China)

机构地区：[1]浙江大学医学院附属邵逸夫医院钱塘院区药学部,杭州310018 [2]浙江大学医学院附属邵逸夫医院钱塘院区新生儿重症监护室,杭州310018 [3]杭州医学院药学院,杭州311399

出　　处：《中国药学杂志》2023年第21期1977-1982,共6页Chinese Pharmaceutical Journal

基　　金：浙江省自然基金项目资助(LYY19H300002);浙江省医学会临床科研基金项目资助(2020ZYC-A411);杭州市医药卫生科技项目资助(A20200682)。

摘　　要：目的 比较多种油脂肪乳剂(multi-oil fat emulsion, SMOFlipid)和大豆油脂肪乳剂(soybean oil-fat emulsion, Intralipid)分别应用于极低出生体重儿(very low birth weight infants, VLBW)肠外营养的安全性。方法 通过回顾性病历数据研究,选取我院2016年至2022年新生儿科收治的VLBW为研究对象,根据纳入标准和排除标准,比较Intralipid组和SMOFlipid组VLBW的临床特征、临床并发症及相关治疗结局。结果 共有273例VLBW被纳入研究,Intralipid组117例,SMOFlipid组156例。两组研究对象在出生胎龄、性别和体重等方面相似。SMOFlipid与较短的住院时间相关(68 d vs. 81 d,P<0.001)。SMOFlipid组的视网膜疾病发病率较低(31.4%vs. 46.2%,P=0.013),但多因素回归分析表明差异无统计学意义(OR 0.557,95%CI[0.287, 1.082];P=0.084)。两组VLBW在死亡率、胆汁淤积症发生率和支气管肺发育不良等其他疾病发生率方面差异无统计学意义。结论 与Intralipid相比,SMOFlipid在VLBW群体中具有相似的安全性。OBJECTIVE To compare the safety of multi-oil fat emulsion(SMOFlipid)and soybean oil-fat emulsion(Intralipid)in parenteral nutrition of very low birth weight infants(VLBW),respectively.METHODS Through retrospective medical record data study,the VLBW admitted to the neonatal department of our hospital from 2016 to 2022 were selected as the research objects.According to the inclusion and exclusion criteria,the clinical characteristics,clinical complications and related outcomes of VLBW in the Intralipid group and the SMOFlipid group were compared.RESULTS A total of 273 VLBW patients were included in the study,117 in the Intralipid group and 156 in the SMOFlipid group.The two groups were similar in terms of gestational age at birth,sex and weight.SMOFlipid was associated with shorter hospital stay(68 d vs.81 d,P<0.001).The incidence of retinopathy of prematurity was lower in the SMOFlipid group(31.4%vs.46.2%,P=0.013),but multivariate regression analysis showed no statistical difference(OR 0.557,95%CI[0.287,1.082],P=0.084).There were no statistically significant differences in mortality,cholestasis,and other diseases such as bronchopulmonary dysplasia between the two VLBW groups.CONCLUSIONS Compared with Intralipid,SMOFlipid has a similar safety profile in the VLBW population.

关 键 词：肠外营养 极低出生体重儿 脂肪乳剂 

分 类 号：R969.3[医药卫生—药理学]