基于体素的分析方法比较IMRT与VMAT技术在晚期鼻咽癌患者大脑中的剂量差异  

Dosimetric comparison of IMRT versus VMAT for advanced nasopharyngeal carcinoma using voxel-based method

作　　者：杜锋磊[1] 杨一威[1] 邵凯南[1] DU Fenglei;YANG Yiwei;SHAO Kainan(Department of Radiation Physics,Zhejiang Cancer Hospital,Hangzhou 310022,China)

机构地区：[1]浙江省肿瘤医院放射物理科,浙江杭州310022

出　　处：《中国医学物理学杂志》2024年第2期139-144,共6页Chinese Journal of Medical Physics

基　　金：浙江省基础公益研究计划(LGF22H160070);浙江省医药卫生科技项目(2021PY040)。

摘　　要：目的:定位晚期鼻咽癌患者放疗过程中大脑受照射的确切位置,分析IMRT和VMAT技术在晚期鼻咽癌患者的脑内剂量分布差异。方法:使用蒙特利尔神经学研究所空间中的CT脑模板,采用基于体素的分析方法对脑内的剂量分布进行分析。结果:对于晚期鼻咽癌患者,VMAT计划在保护脑内正常组织方面并没有表现出优势,相反,IMRT计划更加出色,IMRT计划表现出优势的区域包括脑干、小脑后叶、小脑前叶、颞叶、枕叶、边缘叶以及叶下回的部分区域。结论:对晚期鼻咽癌患者,VMAT在保护正常脑组织方面显示出劣势,提示IMRT方法对正常脑组织的保护可能更有优势。Objective To identify the exact locations of the brain being irradiated in advanced nasopharyngeal carcinoma(NPC) patients during radiotherapy,and to analyze the differences in brain dose distribution between advanced NPC patients treated with intensity-modulated radiotherapy(IMRT) and volumetric modulated arc therapy(VMAT).Methods Based on the CT brain template provided by the Montreal Neurological Institute,the brain dose distribution was analyzed with voxelbased method.Results For advanced NPC patients,VMAT plans did not demonstrate superiority in normal brain tissue sparing,while IMRT performed better,with advantages observed in regions such as the brainstem,the posterior lobe of the cerebellum,the anterior lobe of the cerebellum,temporal lobes,occipital lobes,limbic lobes,and certain areas of the subcortical regions.Conclusion IMRT is advantageous over VMAT in protecting the normal brain tissues in advanced NPC patients.

关 键 词：鼻咽癌 放射治疗 CT脑模板 剂量学 

分 类 号：R318[医药卫生—生物医学工程] R811.1[医药卫生—基础医学]