电磁脉冲引起人体血脑屏障开放的生物电磁剂量学  

Bioelectromagnetic dosimetric study of human blood-brain barrier opening induced by electromagnetic pulse

作　　者：林加金 周艳 丁桂荣 李静 LIN Jiajin;ZHOU Yan;DING Guirong;LI Jing(Department of Radiation Biology,Faculty of Preventive Medicine,Air Force Medical University/Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment,Xi'an 710032,China)

机构地区：[1]空军军医大学军事预防医学系辐射防护医学教研室/特殊作业环境危害评估与防治教育部重点实验室,陕西西安710032

出　　处：《中国医学物理学杂志》2024年第2期241-246,共6页Chinese Journal of Medical Physics

基　　金：国家自然科学基金(31770905,31500679)。

摘　　要：目的:对电磁脉冲引起人体血脑屏障开放的生物电磁剂量学进行研究。方法:基于典型暴露平台建立人体脑部剂量学研究环境,利用三维数字化人体模型并结合电磁仿真方法对生物电磁剂量进行仿真评估。结果:头部中心的电场峰值为1.49 kV/m,与激励电场相比衰减41.6 dB;鼻尖皮肤表面处空气中最大电场幅值为1795 kV/m;一次脉冲下头部空间的平均吸收率为4.16×10^(-8)J/kg;重复频率1 000 s^(-1)的极端条件下的头部平均比吸收率为4.16×10^(-5)W/kg。结论:局部高强度电场是临床应用中重要的安全隐患,需要结合血脑屏障开放的量效关系研究抑制局部高强度电场的手段,本研究的人体脑部生物电磁剂量数据可用于临床效应的可行性评估。Objective To analyze the bioelectromagnetic dose of human blood-brain barrier opening induced by electromagnetic pulse.Methods A typical exposure platform was used to establish an environment for human brain dosimetric study.The bioelectromagnetic dose was evaluated with electromagnetic simulation method using a 3D digital human model.Results The electric field at the centre of the head reached a peak of 1.49 kV/m,and there was a decrease of41.6 dB from the excitation field.The maximum electric field amplitude on the surface of the nose tip was 1 795 kV/m.The head had an average absorption rate of 4.16×10~(-8)J/kg under one pulse,while under extreme conditions with a repetition frequency of 1 000 s~(-1),the average specific absorption rate of the head was 4.16×10~(-5)W/kg.Conclusion Local high-intensity electric fields pose significant safety risks in clinical application,and it is necessary to study the means of inhibiting local high-intensity electric field in combination with the dose-effect relationship of blood-brain barrier opening.The human brain bioelectromagnetic doses provided by the study can be used to evaluate the clinical efficacy.

关 键 词：电磁脉冲 血脑屏障 临床应用 剂量 生物安全性 

分 类 号：R318[医药卫生—生物医学工程] Q64[医药卫生—基础医学]