儿童体位性心动过速综合征的个体化治疗  

Individualized treatment for pediatric postural orthostatic tachycardia syndrome

作　　者：崔雅茜 金红芳[1,2] Cui Yaxi;Jin Hongfang(Department of Pediatrics,Peking University First Hospital,Beijing 100034,China;State Key Laboratory of Vascular Homeostasis and Remodeling,Peking University,Beijing 100191,China)

机构地区：[1]北京大学第一医院儿科,100034 [2]血管稳态与重构全国重点实验室,北京100191

出　　处：《中国小儿急救医学》2023年第12期891-896,共6页Chinese Pediatric Emergency Medicine

基　　金：中央高水平医院临床科研基金(北京大学第一医院国内多中心临床研究专项(2022CR59))。

摘　　要：体位性心动过速综合征(POTS)是导致儿童和青少年时期晕厥的常见疾病之一,主要表现为一系列慢性直立不耐受症状和直立后异常的心动过速,严重影响儿童和青少年的学习和生活质量。POTS在临床表现、病理生理机制和相关并发症上存在着多样性和异质性,因此仅依赖经验来选择治疗方案往往不能达到预期的临床效果。进一步研究能预测POTS治疗效果的临床生物标志物并进行个体化治疗,对于提高患者的临床预后和生活质量具有至关重要的意义。本文深入探索了POTS临床疗效预测中生物标志物的最新研究成果,旨在为儿童POTS的临床治疗策略提供新的视角和思路。Postural orthostatic tachycardia syndrome(POTS)is a common condition that results in syncope among children and adolescents.It primarily manifests as a range of chronic orthostatic intolerance symptoms,accompanied by an abnormal increase in heart rate upon standing,significantly impacting the learning and quality of life in young individuals.POTS demonstrates diversity and heterogeneity in clinical symptoms,underlying pathophysiological mechanisms,and associated complications.Consequently,relying on experience to treatment often fails to achieve desired clinical outcomes.Delving deeper into potential clinical biomarkers capable of predicting POTS treatment efficacy and implementing individualized treatment approaches are crucial for enhancing patient prognosis and quality of life.This review provided a comprehensive exploration of the latest research findings on biomarkers for predicting POTS clinical outcomes,aiming to offer perspectives and approaches for the clinical treatment of pediatric POTS.

关 键 词：儿童 体位性心动过速综合征 病理生理机制 个体化治疗 

分 类 号：R725.4[医药卫生—儿科]