A digital bridge to reverse paralysis  

作　　者：Laureen D.Hachem Gustavo Balbinot Michael G.Fehlings 

机构地区：[1]Division of Genetics and Development,Krembil Research Institute,University Health Network,Toronto,ON,Canada [2]Division of Neurosurgery,Department of Surgery,University of Toronto,Toronto,ON,Canada

出　　处：《Cell Research》2023年第12期892-893,共2页细胞研究（英文版）

基　　金：support from the Robert Campeau Family Foundation/Dr.C.H.Tator Chair in Brain and Spinal Cord Research at UHN.

摘　　要：Injury to the spinal cord can disrupt the neural circuits necessary for locomotion.In a recent paper published in Nature,Lorach et al.demonstrate the feasibility of implementing a‘digital bridge’between the brain and spinal cord to improve locomotor function in an individual with chronic spinal cord injury.Injury to the spinal cord causes disruption of the neural circuits that underlie locomotor activity and creates a hostile environment that is inhibitory to regeneration.While several strategies have aimed to ameliorate the inhibitory microenvironment of the injured spinal cord to facilitate axon regrowth and restore damaged circuits,these approaches have been met with significant challenges and to date there remains no effective treatment for spinal cord injury(SCI).Novel strategies that aim to stimulate spared circuitry or bypass the lesion epicentre have shown promise in improving locomotor function after SCI.

关 键 词：BRIDGE DIGITAL CENTRE 

分 类 号：R651.2[医药卫生—外科学]