An idle PHGDH takes control of cell fate  

作　　者：Linchong Sun Ping Gao 

机构地区：[1]Medical Research Institute,Guangdong Provincial People’s Hospital,Guangdong Academy of Medical Sciences,Southern Medical University,Guangzhou,Guangdong,China

出　　处：《Cell Research》2023年第12期894-895,共2页细胞研究（英文版）

摘　　要：Multifunctional metabolites are widely involved in physiological and pathological processes as signaling molecules,sensors,epigenetic modification substrates and so on,in addition to being energy substances.In a recent Cell Research study,Wu et al.make a remarkable discovery that,when the level of 3-phosphoglycerate,a typical metabolite at the crossroads of glucose catabolism and serine anabolism,is low,the unoccupied 3-phosphoglycerate dehydrogenase is redirected to watch the cell fate.One of the simplest but most precious gifts nature has given to human beings is glucose.It provides energy for biological processes and is involved in biosynthesis in almost all heterotrophic organisms,including humans.Because of its unique structure and involvement in heavily divergent metabolic pathways,glucose can control all aspects of life.The traditional roles of metabolic enzymes and their respective metabolites in glucose metabolism are to provide ATP and biomacromolecules in the course of cellular life.

关 键 词：occupied ADDITION METABOLISM 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]