A broadly neutralizing antibody inhibits SARS-CoV-2 variants through a novel mechanism of disrupting spike trimer integrity  

作　　者：Yunping Ma Qiyu Mao Yingdan Wang Zhaoyong Zhang Jiali Chen Aihua Hao Palizhati Rehati Yanqun Wang Yumei Wen Lu Lu Zhenguo Chen Jincun Zhao Fan Wu Lei Sun Jinghe Huang 

机构地区：[1]Key Laboratory of Medical Molecular Virology(MOE/NHC/CAMS)and Shanghai Institute of Infectious Disease and Biosecurity,Shanghai Public Health Clinical Center,Shanghai Fifth People’s Hospital,Institutes of Biomedical Sciences,School of Basic Medical Sciences,Fudan University,Shanghai,China [2]Shanghai Immune Therapy Institute,Shanghai Jiao Tong University School of Medicine Affiliated Renji Hospital,Shanghai,China [3]State Key Laboratory of Respiratory Disease,National Clinical Research Center for Respiratory Disease,Guangzhou Institute of Respiratory Health,the First Affiliated Hospital of Guangzhou Medical University,Guangzhou,Guangdong,China [4]Shanghai Institute for Advanced Immunochemical Studies,School of Life Science and Technology,Shanghai Tech University,Shanghai,China

出　　处：《Cell Research》2023年第12期975-978,共4页细胞研究（英文版）

基　　金：supported by the National Natural Science Foundation of China(32370995 and 31771008 to J.H.and 3197014 to Z.C.);the Shanghai Municipal Science and Technology Major Project(ZD2021CY001 to J.H.);the Ministry of Science and Technology of China(2021YFC2302500 to L.S.);the National Youth Talent Support Program(2022 to F.W.);the“Shuguang Program”of Shanghai Education Development Foundation and Shanghai Municipal Education Commission(22SG16 to F.W.);Guangzhou Laboratory(SRPG22-003 to L.S.);the National Science and Technology Major Projects of China(2017ZX10202102 to J.H.and 2018ZX10301403 to F.W.).

摘　　要：Dear Editor,Since the start of the COVID-19 pandemic,thousands of neutralizing antibodies(NAbs)targeting different epitopes of the spike protein have been identifed and characterized.1-3 However,the emergence of the Omicron variant and its subvariants has raised global concern due to their resistance to most reported monoclonal antibodies and dramatically decreases the immune effcacy of current Vaccines.4sA newly emerging,subvariant XBB.1.16 that is rapidly disseminating on a global scale has been associated with a previously unreported symptom of red or pink eye.Compared to XBB.1.5,XBB.1.16 harbors two additional mutations,E180V and K478R,which are hypothesized to confer enhanced transmissibility and antigenic escape.?

关 键 词：NEUTRAL sized HARBOR 

分 类 号：R373[医药卫生—病原生物学]