胰岛素样生长因子-1在脑垂体腺瘤中的表达及临床意义  

Expression and Clinical Significance of Insulin-like Growth Factor-1 in Pituitary Adenomas

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作  者:张玥熠 张玉垲 杨青[1] 袁昌丽 ZHANG Yueyi;ZHANG Yukai;YANG Qing(Department of Nuclear Medicine,The Second Affiliated Hospital of Kunming Medical University,Yunnan 650101,China)

机构地区:[1]昆明医科大学第二附属医院核医学科,650101 [2]昆明医科大学第一附属医院胸外科,650101

出  处:《医学研究杂志》2024年第2期86-90,共5页Journal of Medical Research

基  金:云南省教育厅科学研究基金项目(2019J1260)。

摘  要:目的分析垂体腺瘤患者血清中胰岛素样生长因子-1(insulin-like growth factor-1,IGF-1)的表达并按照不同标准进行分组比较,探讨IGF-1在垂体腺瘤中的表达及其临床意义。方法选取2019年1月~2021年6月昆明医科大学第二附属医院收治的156例垂体腺瘤作为试验组,选取同期健康体检者22例作为对照组。采用磁微粒化学发光法测定血清IGF-1水平。综合磁共振成像(magnetic resonance imaging,MRI)测量所得最大径与术后肿瘤病理标本所得肿瘤最大径,将试验组按照不同临床特征进行分组,比较各亚组及对照组的IGF-1水平差异。结果生长激素细胞腺瘤、双激素和多激素细胞腺瘤患者IGF-1水平高于对照组及其余类型,差异均有统计学意义(P<0.05);巨腺瘤患者IGF-1水平高于对照组及其余类型,差异有统计学意义(P<0.05);侵袭性垂体腺瘤患者IGF-1水平高于非侵袭性患者及对照组,差异有统计学意义(P<0.05)。Logistic回归分析结果表明,IGF-1水平和肿瘤最大径为垂体腺瘤有侵袭性的危险因素,且IGF-1水平越高、肿瘤最大径越大,侵袭性风险越高;垂体腺瘤患者术后1个月内的IGF-1水平相较于术前有明显降低,差异有统计学意义(P<0.05)。结论IGF-1对不同功能类型垂体腺瘤的鉴别诊断、对垂体腺瘤早期侵袭性判断有一定价值,并有望作为术后随访的一项可信指标。Objective To analyze the expression of insulin-like growth factor-1(IGF-1)in the serum of patients with pituitary adenomas and compare them according to different standards,investigating the expression of IGF-1 in pituitary adenoma and its clinical significance.Methods A total of 156 cases of pituitary adenomas admitted to the Second Affiliated Hospital of Kunming Medical University from January 2019 to June 2021 were selected as the experimental group,and a total of 22healthy subjects during the same period were selected as the control group.To determinate the IGF-1 level by magnetic particle chemical luminescence immunoassay.The tumor diameter was obtained by combining the diameter measured on magnetic resonance imaging(MRI)with the diameter of postoperative tumor pathological specimen.The experimental group were divided into groups according to different clinical characteristics,and to compare the differences in IGF-1 levels between each subgroup and the control group.Results The levels of IGF-1 in patients with somatotroph adenoma,dual hormone and multihormone adenoma were higher than those in the control group and other types,and the differences were statistically significant(P<0.05);the level of IGF-1 in giant adenoma patients was higher than those in the control group and other types,and the difference was statistically significant(P<0.05);the level of IGF-1 in patients with invasive pituitary adenoma was higher than that in non-invasive patients and controls,and the difference was statistically significant(P<0.05);Logistic regression analysis showed that IGF-1 level and tumor diameter were risk factors for invasiveness of pituitary adenomas,the higher the IGF-1 level and the larger the tumor diameter,the higher the invasiveness risk;the level of IGF-1 in patients with pituitary adenoma within one month after surgery was significantly lower than that before surgery,and the difference was statistically significant(P<0.05).Conclusion IGF-1 has a certain value in the diagnosis of different functional types of

关 键 词:胰岛素样生长因子-1 垂体腺瘤 侵袭性 磁共振成像 

分 类 号:R446.11[医药卫生—诊断学]

 

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