清胰汤加减对急性胰腺炎患者肠道菌群及肠黏膜功能的影响  

Effects of Qingyi Decoction add or subtract on intestinal flora and intestinal mucosal function in patients with acute pancreatitis

作　　者：闫铁静 王宏[2] 安莹 YAN Tiejing;WANG Hong;AN Ying(Pharmacy Department of Qinhuangdao Traditional Chinese Medicine Hospital,Qinhuangdao,Hebei 066000,China;不详)

机构地区：[1]秦皇岛市中医医院药剂科,河北066000 [2]秦皇岛市中医医院脾胃科,河北066000 [3]秦皇岛市中医医院膏方煎药室,河北066000

出　　处：《中国微生态学杂志》2023年第11期1329-1333,共5页Chinese Journal of Microecology

基　　金：2021年秦皇岛市市级科学技术研究与发展计划自筹经费(202101A061)。

摘　　要：目的 探讨清胰汤加减对急性胰腺炎患者肠道菌群及肠黏膜功能的影响,为该类患者的治疗提供参考。方法 选取我院2020年1月至2022年6月收治的急性胰腺炎患者108例,随机分为联合组(54例)和常规组(54例)。常规组患者采用常规西药治疗,联合组患者给予清胰汤加减联合常规西药治疗。比较2组患者治疗前后的中医症状积分、肠道菌群数量、肠黏膜功能(D-乳酸、二胺氧化酶、内毒素、白介素-6)情况,比较2组患者临床疗效及不良反应。结果 治疗后,2组患者主症、次症积分均降低,且联合组低于常规组(均P<0.05)。治疗后,2组患者肠道大肠埃希菌、葡萄球菌属数量均降低,且联合组上述菌群数量均低于常规组(均P<0.05)。治疗后,2组患者肠道双歧杆菌属、乳杆菌属数量均升高,且联合组上述菌群数量均高于常规组(均P<0.05)。治疗后,2组患者血清D-乳酸、二胺氧化酶、内毒素、白介素-6水平均降低,且联合组均低于常规组(均P<0.05)。联合组患者临床有效率高于常规组(96.30%vs 83.33%,P<0.05),而2组患者不良反应发生率比较差异无统计学意义(P>0.05)。结论 清胰汤加减对急性胰腺炎患者的治疗效果显著,能够显著改善患者肠黏膜功能,调节肠道菌群水平,安全性较高。Objective To observe the effects of Qingyi (pancreas cleansing) Decoction variant formula (QDVF) on intestinal flora and intestinal mucosal function in patients with acute pancreatitis (AP), providing a reference for the treatment. Methods A total of 108 patients with AP admitted to our unit from January 2020 to June 2022 were randomly divided into combination group (54 cases) or convention group (54 cases). The convention group was treated with conventional Western medicine, while the combination group was treated with QDVF combined with conventional Western medicine. The Chinese medicine symptom score, intestinal flora level, and intestinal mucosal function (D-lactic acid, diamine oxidase, endotoxin, interleukin-6) before and after treatment, as well as the clinical efficacy and adverse reactions were compared between the two groups. Results After treatment, the main disease and secondary disease scores in both groups decreased, with that in combination group being lower (all P<0.05);the counts of Escherichia coli and Staphylococcus in both groups decreased, with those in the combination group lower than those in convention group (all P<0.05);the counts of Bifidobacterium and Lactobacillus increased in both groups, with those in combination group higher than those in convention group (all P<0.05). After treatment, the levels of serum D-lactic acid, diamine oxidase, endotoxin and interleukin-6 in both groups decreased, with the combination group superior to the convention group (all P<0.05). The clinical cfficiency rate in combination group was higher than that in convention group (96.30% vs 83.33%, P<0.05). There was no difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion Qingyi Decoction variant formula can significantly improve the intestinal mucosal function of patients with acute pancreatitis, regulate the intestinal flora, and have high safety.

关 键 词：肠道菌群 肠黏膜功能 急性胰腺炎 清胰汤加减 

分 类 号：R657.5[医药卫生—外科学]