Critical approaches in the catalytic transformation of sugar isomerization and epimerization after Fischer-History,challenges,and prospects  

作　　者：Da-Ming Gao Xun Zhang Haichao Liu Hidemi Fujino Tingzhou Lei Fuan Sun Jie Zhu Taoli Huhe 

机构地区：[1]National-local Joint Engineering Research Center of Biomass Refine and High-Quality Utilization,Changzhou University,Changzhou,213164,China [2]Institute of Urban and Rural Mining Research,Changzhou University,Changzhou,213164,China [3]Changzhou Key Laboratory of Biomass Green,Safe&High Value Utilization,Changzhou University,Changzhou,213164,China [4]Beijing National Laboratory for Molecular Science,College of Chemistry and Molecular Engineering,Peking University,Beijing,100871,China [5]Department of Rehabilitation Science,Kobe University Graduate School of Health Sciences,Kobe,654-0142,Japan

出　　处：《Green Energy & Environment》2024年第3期435-453,共19页绿色能源与环境（英文版）

基　　金：Financial support by Dual Initiative Project of Jiangsu Province and Changzhou University is gratefully acknowledged;Sample analysis supported by Analysis and Testing Center,NERC Biomass of Changzhou University was also greatly acknowledged.

摘　　要：The transformation of aldose to ketose or common sugars into rare saccharides,including rare ketoses and aldoses,is of great value and interest to the food industry and for saccharidic biomass utilization,medicine,and the synthesis of drugs.Nowadays,high-fructose corn syrup(HFCS)is industrially produced in more than 10 million tons annually using immobilized glucose isomerase.Some low-calorie saccharides such as tagatose and psicose,which are becoming popular sweeteners,have also been produced on a pilot scale in order to replace sucrose and HFCS.However,current catalysts and catalytic processes are still difficult to utilize in biomass conversion and also have strong substrate dependence in producing high-value,rare sugars.Considering the specific reaction properties of saccharides and catalysts,since the pioneering discovery by Fischer,various catalysts and catalytic systems have been discovered or developed in attempts to extend the reaction pathways,improve the reaction efficiency,and to potentially produce commercial products.In this review,we trace the history of sugar isomerization/epimerization reactions and summarize the important breakthroughs for each reaction as well as the difficulties that remain unresolved to date.

关 键 词：Rare sugars ISOMERIZATION KETONIZATION EPIMERIZATION Catalytic transformation 

分 类 号：TQ281[化学工程—有机化工] TQ203.2