S100-β蛋白和髓鞘碱性蛋白对早产儿脑损伤的早期诊断价值  

Diagnostic value of S100-βprotein and myelin basic protein(MBP)in early diagnosis of brain injury in premature infants

作　　者：赖本聪 陈旭铭 罗琼 肖珮 LAI Ben-cong;CHEN Xu-ming;LUO Qiong;XIAO Pei(Department of Neonatology,Songshan Lake Central Hospital,Dongguan 523000,Guangdong,China)

机构地区：[1]东莞市松山湖中心医院新生儿科,广东东莞523000

出　　处：《川北医学院学报》2024年第2期218-221,共4页Journal of North Sichuan Medical College

基　　金：广东省东莞市社会发展科技面上项目(20211800900832)。

摘　　要：目的:探讨S100-β和血清髓磷脂碱性蛋白(MBP)对早产儿脑损伤早期的诊断价值。方法:选取139例早产儿为研究对象,根据颅脑MRI和超声检查结果分为脑损伤组(n=34)和无脑损伤组(n=105)。比较两组早产儿动脉血气指标[二氧化碳分压(PCO_(2))、pH值及氧分压(PO_(2))]、血清S100-β和MBP水平,分析脑损伤患儿S100-β和MBP水平与新生儿神经行为(NBNA)评分的相关性及其对脑损伤早产儿预后的早期诊断价值。结果:无脑损伤早产儿组第1、3、7天PCO_(2)低于脑损伤组(P<0.05),pH值和PO_(2)高于脑损伤组(P<0.05)。脑损伤早产儿血清S100-β和MBP高于无脑损伤组(P<0.05)。脑损伤患儿血清MBP和S100-β水平与新生儿NBNA评分负相关(P<0.05)。血清S100-β和MBP对诊断早产儿脑损伤的ROC曲线下面积分别为0.912(95%CI:0.856~0.968)和0.787(95%CI:0.702-0.872)。结论:脑损伤早产儿呼吸及酸碱平衡存在异常,其中患儿血清S100-β和MBP水平是早期预测早产脑损伤和评估新生儿神经发育状况的潜在指标,可为早期诊断和干预提供重要参考。Objective:To explore the diagnostic value of S100 B and serum myelin basic protein(MBP)in the early diagnosis of brain injury in premature infants.Methods:139 premature infants were selected as the research objects.According to the results of craniocerebral MRI and ultrasonograp,they were divided into 34 cases of premature brain injury group and 105 cases of premature non-brain injury group.Arterial blood gas indicators[partial pressure of carbon dioxide(PCO_(2)),pH value,and partial pressure of oxygen(PO_(2))],and levels of serum S100-βand MBP were compared between two groups.The correlation between S100-βand MBP levels in children with brain injury and neonatal neurobehavioral(NBNA)scores,and their early diagnostic value for the prognosis of premature infants with brain injury were analyzed.Results:The PCO_(2) of the preterm in non-brain injury group was lower on the 1,3 and 7 d than that in brain injury group(P<0.05),and the pH value and PO_(2) were higher than those in brain injury group(P<0.05).Serum S100-βand MBP levels were increased in preterm infants with brain injury(P<0.05).The levels of serum MBP and S100-βin preterm infants with brain injury were negatively correlated with neonatal NBNA score(P<0.05).The area under the ROC curve of serum S100-βand MBP for the diagnosis of brain injury in preterm infants was 0.912(95%CI=0.856~0.968)and 0.787(95%CI=0.702~0.872),respectively.Conclusion:There are significant abnormalities in respiration and acid-base balance in premature infants with preterm brain injury.Serum S100-βand MBP levels are potential indicators for early prediction and evaluation of neonatal neurodevelopment providing an important basis for early diagnosis and intervention.

关 键 词：早产脑损伤 早产儿 生理特征 血清标志物 

分 类 号：R722.6[医药卫生—儿科]