LISA技术和INSURE技术在早产儿NRDS中的疗效  

Therapeutic effects of LISA and INSURE on premature infants with NRDS

作　　者：张磊 范志刚 许彬 龚志敏 ZHANG Lei;FAN Zhi-gang;XU Bin;GONG Zhi-min(Department of Neonatology,Maanshan Maternal and Child Health Care Hospital,Maanshan 243000,Anhui,China)

机构地区：[1]马鞍山市妇幼保健院新生儿科,安徽马鞍山243000

出　　处：《川北医学院学报》2024年第2期265-268,共4页Journal of North Sichuan Medical College

摘　　要：目的:探讨经细管肺表面活性物质注入(LISA)技术和气管插管-肺表面活性物质-拔管(INSURE)技术在新生儿呼吸窘迫综合征(NRDS)早产儿中的治疗效果。方法:将60例NRDS早产患儿按照治疗方案不同分为A组(n=31)和B组(n=29),所有研究对象均给予常规治疗,A组采用LISA技术治疗;B组采用INSURE技术治疗。比较两组患儿临床疗效、用药过程中的相关指标及插管所需时间、无创通气时间、住院时间,记录两组患儿并发症发生情况。结果:A组临床总有效率(93.56%)较B组(72.41%)更高(P<0.05);A组SpO_(2)降低、心动过缓发生率及72 h内机械通气使用率均低于B组(P<0.05),两组再次使用PS发生率比较,差异无统计学意义(P>0.05);A组插管所需时间、无创通气时间及住院时间均短于B组(P<0.05);A组各项并发症发生率均略低于B组,并发症总发生率略低于B组,但差异无统计学意义(P>0.05)。结论:相较于INSURE技术,LISA技术对NRDS早产儿具有更好的治疗效果。Objective:To explore the therapeutic effects of less invasive surfactant administration(LISA)and intubation-surfactant-extubation(INSURE)on premature infants with neonatal respiratory distress syndrome(NRDS).Methods:60 premature infants with NRDS were divided into group A(n=31)and group B(n=29)according to different treatment plans.All subjects were given conventional treatment.On this basis,group A was treated with LISA,and group B was treated with INSURE.The clinical efficacy,relevant indicators during medication,the time required for intubation,duration of non-invasive ventilation and length of hospital stay were compared between the two groups.The incidence rates of complications were recorded.Results:The total clinical response rate in group A was higher than that in group B(93.56%vs.72.41%,P<0.05).The incidence rates of SpO_(2) reduction and bradycardia,and usage rate of mechanical ventilation within 72 h in group A were lower than those in group B(P<0.05).There were no statistically significant difference in the incidence of PS reuse between the two groups(P>0.05).The intubation time,non-invasive ventilation time and hospital stay of group A were shorter than those of group B(P<0.05).The incidence rates of complications in group A were lower than those in group B,and the overall incidence of complications was lower than that in Group B,but the differences were not statistically significant(P>0.05).Conclusion:Compared with INSURE,LISA is more effective for premature infants with NRDS.

关 键 词：新生儿呼吸窘迫综合征 早产 经细管肺表面活性物质注入技术 气管插管-肺表面活性物质-拔管技术 并发症 

分 类 号：R725.63[医药卫生—儿科]